Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats : A Pilot Study with 18F-Fluorodeoxyglucose MicroPET
المؤلفون المشاركون
Li, Jin-hui
Zhang, Hong
Lu, Jing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To investigate neuroprotective effects of scutellarin (Scu) in a rat model of cerebral ischemia with use of 18F-fluorodeoxyglucose (18F-FDG) micro positron emission tomography (microPET).
Method.
Middle cerebral artery occlusion was used to establish cerebral ischemia.
Rats were divided into 5 groups: sham operation, cerebral ischemia-reperfusion untreated (CIRU) group, Scu-25 group (Scu 25 mg/kg/d), Scu-50 group (Scu 50 mg/kg/d), and nimodipine (10 mg/Kg/d).
The treatment groups were given for 2 weeks.
The therapeutic effects in terms of cerebral infarct volume, neurological deficit scores, and cerebral glucose metabolism were evaluated.
Levels of vascular density factor (vWF), glial marker (GFAP), and mature neuronal marker (NeuN) were assessed by immunohistochemistry.
Results.
The neurological deficit scores were significantly decreased in the Scu-50 group compared to the CIRU group (P<0.001).
18F-FDG accumulation in the ipsilateral cerebral infarction increased steadily over time in Scu-50 group compared with CIRU group (P<0.01) and Scu-25 group (P<0.01).
Immunohistochemical analysis demonstrated Scu-50 enhanced neuronal maturation.
Conclusion.
18F-FDG microPET imaging demonstrated metabolic recovery after Scu-50 treatment in the rat model of cerebral ischemia.
The neuroprotective effects of Scu on cerebral ischemic injury might be associated with increased regional glucose activity and neuronal maturation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jin-hui& Lu, Jing& Zhang, Hong. 2013. Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats : A Pilot Study with 18F-Fluorodeoxyglucose MicroPET. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-477109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jin-hui…[et al.]. Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats : A Pilot Study with 18F-Fluorodeoxyglucose MicroPET. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-477109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jin-hui& Lu, Jing& Zhang, Hong. Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats : A Pilot Study with 18F-Fluorodeoxyglucose MicroPET. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-477109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر