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Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma
المؤلفون المشاركون
Ma, Ning
Hiraku, Yusuke
Zhang, Zhe
Oikawa, Shinji
Kawanishi, Shosuke
Wang, Shumin
Huang, Guangwu
Xie, Ying
Murata, Mariko
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Nasopharyngeal carcinoma (NPC) is one of the most prevalent malignant tumors with poor prognosis in Southern China and Southeast Asia.
Angiogenesis-related molecules can be promising therapeutic targets in NPC.
To investigate the relationships of cancer-associated fibroblasts (CAFs) and chemokine-related molecules with neoangiogenesis, we compared immunohistochemical analyses of alpha-smooth-muscle actin (α-SMA), stroma-derived factor-1 (SDF-1), and its receptor CXCR4 in primary NPC specimens and chronic nasopharyngitis tissues.
In addition, we examined the expression of vascular endothelial growth factor (VEGF-A), and CD133- and VEGF- receptor-2 (VEGFR-2) double positive cells, as endothelial progenitor cells (EPCs).
We also assessed CD34-positive microvessels.
Significantly higher expression of α-SMA was observed in fibroblasts in NPC stroma.
The immunoreactive intensities of SDF-1 and CXCR4 were significantly higher in NPC cells.
CXCR4-positive cells and CD133/VEGFR-2- double positive cells were observed in the stroma surrounding cancer nests, and VEGF was detected in both cancer and stromal cells.
Microvessel density was significantly higher in the stroma of NPC tissues compared to chronic nasopharyngitis tissues.
Our data suggest that CAFs and NPC tumor cells may enhance neoangiogenesis in a VEGF- and SDF-1-dependent manner by recruiting EPCs from the bone marrow into tumor stroma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shumin& Ma, Ning& Kawanishi, Shosuke& Hiraku, Yusuke& Oikawa, Shinji& Xie, Ying…[et al.]. 2014. Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477137
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shumin…[et al.]. Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-477137
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shumin& Ma, Ning& Kawanishi, Shosuke& Hiraku, Yusuke& Oikawa, Shinji& Xie, Ying…[et al.]. Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477137
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477137
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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