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The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat
المؤلفون المشاركون
Xu, Peng
Zhou, Yuwen
Liu, Haiyan
Cao, Xuebin
Wang, Yunru
Wang, Yang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Objective.
To investigate the protection of salidroside of the heart against acute exhaustive injury and its mechanism of antioxidative stress and MAPKs signal transduction.
Method.
Adult male SD rats were divided into four groups randomly.
Cardiomyocytes ultrastructure was observed by optical microscopy and transmission electron microscopy.
The contents of CK, CK-MB, LDH, MDA, and SOD were determined by ELISA method, and the phosphorylation degrees of ERK and p38 MAPK were assayed by Western blotting.
Cardiac function of isolated rat heart ischemia/reperfusion was detected by Langendorff technique.
Results.
Salidroside reduced the myocardium ultrastructure injury caused by exhaustive swimming, decreased the contents of CK, CK-MB, and LDH, improved the LVDP, ±LV dp/dtmax under the basic condition, reduced the content of MDA and the phosphorylation degree of p38 MAPK, and increased the content of SOD and the phosphorylation degree of ERK in acute exhaustive rats.
Conclusion.
Salidroside has the protection of the heart against acute exhaustive injury.
The cardioprotection is mainly mediated by antioxidative stress and MAPKs signal transduction through reducing the content of MDA, increasing the content of SOD, and increasing p-ERK and decreasing p-p38 protein expressions in rat myocardium, which might be the mechanisms of the cardioprotective effect of salidroside.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yunru& Xu, Peng& Wang, Yang& Liu, Haiyan& Zhou, Yuwen& Cao, Xuebin. 2013. The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-477177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yunru…[et al.]. The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-477177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yunru& Xu, Peng& Wang, Yang& Liu, Haiyan& Zhou, Yuwen& Cao, Xuebin. The Protection of Salidroside of the Heart against Acute Exhaustive Injury and Molecular Mechanism in Rat. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-477177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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