Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression
المؤلفون المشاركون
Colantuoni, Vittorio
Pancione, Massimo
Remo, Andrea
المصدر
Pathology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Colorectal cancer (CRC) is one of the most common causes of death, despite decades of research.
Initially considered as a disease due to genetic mutations, it is now viewed as a complex malignancy because of the involvement of epigenetic abnormalities.
A functional equivalence between genetic and epigenetic mechanisms has been suggested in CRC initiation and progression.
A hallmark of CRC is its pathogenetic heterogeneity attained through at least three distinct pathways: a traditional (adenoma-carcinoma sequence), an alternative, and more recently the so-called serrated pathway.
While the alternative pathway is more heterogeneous and less characterized, the traditional and serrated pathways appear to be more homogeneous and clearly distinct.
One unsolved question in colon cancer biology concerns the cells of origin and from which crypt compartment the different pathways originate.
Based on molecular and pathological evidences, we propose that the traditional and serrated pathways originate from different crypt compartments explaining their genetic/epigenetic and clinicopathological differences.
In this paper, we will discuss the current knowledge of CRC pathogenesis and, specifically, summarize the role of genetic/epigenetic changes in the origin and progression of the multiple CRC pathways.
Elucidation of the link between the molecular and clinico-pathological aspects of CRC would improve our understanding of its etiology and impact both prevention and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pancione, Massimo& Remo, Andrea& Colantuoni, Vittorio. 2012. Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression. Pathology Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-477310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pancione, Massimo…[et al.]. Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression. Pathology Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-477310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pancione, Massimo& Remo, Andrea& Colantuoni, Vittorio. Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-477310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر