Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions
المؤلفون المشاركون
Cavazzana, Andrea O.
Cattano, Davide
Ma, Daqing
Giunta, Francesco
Valleggi, Simona
Patel, Chirag B.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Xenon can induce cell and organ protection through different molecular mechanisms related to oxygen level.
We explored the effect of xenon on oxygen-related signalling in the central nervous system via hypoxia inducible factor 1 alpha (HIF-1α) and mammalian target of rapamycin (mTOR).
Methods.
Postnatal day 7 (P7) Sprague Dawley rats were exposed to 25% oxygen/75% nitrogen (air group) or 25% oxygen/75% xenon (treatment group) for 120 min.
Brains were collected immediately (transcript analysis—relative real-time polymerase chain reaction) or 24 hours (protein analysis—immunohistochemistry) after the 120-minute exposure period; peak anesthetic preconditioning has been previously identified at 24 hours post-exposure.
Results.
HIF-1α transcript and protein levels were found to be increased in xenon-exposed compared to air-exposed brains.
Sustained nuclear translocation of the protein, accounting for an increased activity of HIF-1α, was also noted.
mTOR transcript analysis revealed no significant difference between xenon-exposed and air-exposed brains immediately after the 120-minute exposure.
Conclusion.
Our data suggest that xenon induces the upregulation of HIF-1α transcription and translation, which may contribute to xenon's neuroprotective preconditioning effect.
However, given that xenon exposure did not affect mTOR transcription, further investigation into other signalling cascades mediating xenon’s effects on HIF-1α in developing brain is warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Valleggi, Simona& Patel, Chirag B.& Cavazzana, Andrea O.& Ma, Daqing& Giunta, Francesco& Cattano, Davide. 2011. Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions. ISRN Anesthesiology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Valleggi, Simona…[et al.]. Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions. ISRN Anesthesiology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-477390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Valleggi, Simona& Patel, Chirag B.& Cavazzana, Andrea O.& Ma, Daqing& Giunta, Francesco& Cattano, Davide. Xenon Upregulates Hypoxia Inducible Factor 1 Alpha in Neonatal Rat Brain under Normoxic Conditions. ISRN Anesthesiology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر