Microglia Play a Major Role in Direct Viral-Induced Demyelination
المؤلفون المشاركون
Nag, Soma
Ramachandra, S. G.
Biswas, Kaushiki
Das Sarma, Jayasri
Chatterjee, Dhriti
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Microglia are the resident macrophage-like populations in the central nervous system (CNS).
Microglia remain quiescent, unable to perform effector and antigen presentation (APC) functions until activated by injury or infection, and have been suggested to represent the first line of defence for the CNS.
Previous studies demonstrated that microglia can be persistently infected by neurotropic mouse hepatitis virus (MHV) which causes meningoencephalitis, myelitis with subsequent axonal loss, and demyelination and serve as a virus-induced model of human neurological disease multiple sclerosis (MS).
Current studies revealed that MHV infection is associated with the pronounced activation of microglia during acute inflammation, as evidenced by characteristic changes in cellular morphology and increased expression of microglia-specific proteins, Iba1 (ionized calcium-binding adaptor molecule 1), which is a macrophage/microglia-specific novel calcium-binding protein and involved in membrane ruffling and phagocytosis.
During chronic inflammation (day 30 postinfection), microglia were still present within areas of demyelination.
Experiments performed in ex vivo spinal cord slice culture and in vitro neonatal microglial culture confirmed direct microglial infection.
Our results suggest that MHV can directly infect and activate microglia during acute inflammation, which in turn during chronic inflammation stage causes phagocytosis of myelin sheath leading to chronic inflammatory demyelination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chatterjee, Dhriti& Biswas, Kaushiki& Nag, Soma& Ramachandra, S. G.& Das Sarma, Jayasri. 2013. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chatterjee, Dhriti…[et al.]. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Clinical and Developmental Immunology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chatterjee, Dhriti& Biswas, Kaushiki& Nag, Soma& Ramachandra, S. G.& Das Sarma, Jayasri. Microglia Play a Major Role in Direct Viral-Induced Demyelination. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر