Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis

المؤلفون المشاركون

Mizuno, Nobumasa
Arima, Chinatsu
Tajima, Kazuo
Kawahara, Takeo
Yokoyama, Yukihiro
Takahashi, Takashi
Yanagisawa, Kiyoshi
Matsuo, Keitaro
Kuroyanagi, Yoko
Tomida, Shuta
Yamao, Kenji
Goto, Hidemi
Nagino, Masato
Kusumegi, Miyoko
Takeuchi, Toshiyuki
Ko, Shigeru B. H.

المصدر

International Journal of Proteomics

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-14

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

There is urgent need for biomarkers that provide early detection of pancreatic ductal adenocarcinoma (PDAC) as well as discrimination of autoimmune pancreatitis, as current clinical approaches are not suitably accurate for precise diagnosis.

We used mass spectrometry to analyze protein profiles of more than 300 plasma specimens obtained from PDAC, noncancerous pancreatic diseases including autoimmune pancreatitis patients and healthy subjects.

We obtained 1063 proteomic signals from 160 plasma samples in the training cohort.

A proteomic signature consisting of 7 mass spectrometry signals was used for construction of a proteomic model for detection of PDAC patients.

Using the test cohort, we confirmed that this proteomic model had discrimination power equal to that observed with the training cohort.

The overall sensitivity and specificity for detection of cancer patients were 82.6% and 90.9%, respectively.

Notably, 62.5% of the stage I and II cases were detected by our proteomic model.

We also found that 100% of autoimmune pancreatitis patients were correctly assigned as noncancerous individuals.

In the present paper, we developed a proteomic model that was shown able to detect early-stage PDAC patients.

In addition, our model appeared capable of discriminating patients with autoimmune pancreatitis from those with PDAC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yanagisawa, Kiyoshi& Tomida, Shuta& Matsuo, Keitaro& Arima, Chinatsu& Kusumegi, Miyoko& Yokoyama, Yukihiro…[et al.]. 2012. Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis. International Journal of Proteomics،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-477401

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yanagisawa, Kiyoshi…[et al.]. Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis. International Journal of Proteomics No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-477401

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yanagisawa, Kiyoshi& Tomida, Shuta& Matsuo, Keitaro& Arima, Chinatsu& Kusumegi, Miyoko& Yokoyama, Yukihiro…[et al.]. Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis. International Journal of Proteomics. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-477401

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-477401