Circulating TGF-β1, Glycation, and Oxidation in Children with Diabetes Mellitus Type 1
المؤلفون المشاركون
Kostolanská, Jana
Jakuš, Vladimír
Sapák, Michal
المصدر
Experimental Diabetes Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The present study investigates the relationship between diabetes metabolic control represented by levels of HbA1c, early glycation products-(fructosamine (FAM)), serum-advanced glycation end products (s-AGEs), lipoperoxidation products (LPO), advanced oxidation protein products (AOPP) and circulating TGF-β in young patients with DM1.
The study group consisted of 79 patients with DM1 (8–18 years).
31 healthy children were used as control (1–16 years).
Baseline characteristics of patients were compared by Student’s t-test and nonparametric Mann-Whitney test (Statdirect), respectively.
The correlations between the measured parameters were examined using Pearson correlation coefficient r and Spearman’s rank test, respectively.
A P value<0.05 was considered as statistically significant.
HbA1c was measured by LPLC, s-AGEs spectrofluorimetrically, LPO and AOPP spectrophotometrically and TGF-β by ELISA.
Our results showed that parameters of glycation and oxidation are significantly higher in patients with DM1 than in healthy control.
The level of serum TGF-β was significantly higher in diabetics in comparison with control: 7.1(3.6; 12.6) versus 1.6(0.8; 3.9) ng/mL.
TGF-β significantly correlated with age and duration of DM1.
There was not found any significant relation between TGF-β and parameres of glycation and oxidation.
However, these results do not exclude the association between TGF-β and the onset of diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jakuš, Vladimír& Sapák, Michal& Kostolanská, Jana. 2012. Circulating TGF-β1, Glycation, and Oxidation in Children with Diabetes Mellitus Type 1. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477454
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jakuš, Vladimír…[et al.]. Circulating TGF-β1, Glycation, and Oxidation in Children with Diabetes Mellitus Type 1. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-477454
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jakuš, Vladimír& Sapák, Michal& Kostolanská, Jana. Circulating TGF-β1, Glycation, and Oxidation in Children with Diabetes Mellitus Type 1. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477454
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477454
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر