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Preliminary Study on Hepatocyte-Targeted Phosphorus-31 MRS Using ATP-Loaded Galactosylated Chitosan Oligosaccharide Nanoparticles
المؤلفون المشاركون
Du, Yong-Zhong
Tang, Ke-Zhong
Yu, Ri-Sheng
Wang, Zhi-Kang
Shi, Dan
Chen, Ying
Sun, Jian-Zhong
Zhu, Xiu-Liang
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The clinical applications of hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) remain to be difficult because the changes of phosphates between normal hepatic tissues and pathological tissues are not so obvious, and furthermore, up to now there is few literature on hepatocyte-targeted 31P MRS.
Materials and Methods.
The ATP-loaded Gal-CSO (Gal-CSO/ATP) nanoparticles were prepared and the special cellular uptake of them as evaluated by using HepG-2 tumor cells and A549 tumor cells, respectively.
Two kinds of cells were incubated with the nanoparticles suspension, respectively.
Then were prepared the cell samples and the enhancement efficiency of ATP peaks detected by 31P MRS was evaluated.
Results.
The cellular uptake rate of Gal-CSO/ATP nanoparticles in HepG-2 cells was higher than that in A549 cells.
Furthermore, the enlarged ATP peaks of Gal-CSO/ATP nanoparticles in HepG-2 cells were higher than those in A549 cells in vitro detected by 31P MRS.
Conclusions.
Gal-CSO/ATP nanoparticles have significant targeting efficiency in hepatic cells in vitro and enhancement efficiency of ATP peaks in HepG-2 cells.
Furthermore, 31P MRS could be applied in the research of hepatic molecular imaging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Ri-Sheng& Zhu, Xiu-Liang& Sun, Jian-Zhong& Shi, Dan& Chen, Ying& Wang, Zhi-Kang…[et al.]. 2013. Preliminary Study on Hepatocyte-Targeted Phosphorus-31 MRS Using ATP-Loaded Galactosylated Chitosan Oligosaccharide Nanoparticles. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Ri-Sheng…[et al.]. Preliminary Study on Hepatocyte-Targeted Phosphorus-31 MRS Using ATP-Loaded Galactosylated Chitosan Oligosaccharide Nanoparticles. Gastroenterology Research and Practice No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-477504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Ri-Sheng& Zhu, Xiu-Liang& Sun, Jian-Zhong& Shi, Dan& Chen, Ying& Wang, Zhi-Kang…[et al.]. Preliminary Study on Hepatocyte-Targeted Phosphorus-31 MRS Using ATP-Loaded Galactosylated Chitosan Oligosaccharide Nanoparticles. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477504
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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