Acute Superoxide Radical Scavenging Reduces Blood Pressure but Does Not Influence Kidney Function in Hypertensive Rats with Postischemic Kidney Injury
المؤلفون المشاركون
Jovović, Đurđica
Mihailović-Stanojević, Nevena
Ivanov, Milan
Miloradović, Zoran
Vajić, Una-Jovana
Marković-Lipkovski, Jasmina
Grujić Milanović, Jelica
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Acute kidney injury (AKI) is associated with significant morbidity and mortality in hypertensive surroundings.
We investigated superoxide radical molecules influence on systemic haemodynamic and kidney function in spontaneously hypertensive rats (SHR) with induced postischemic AKI.
Experiment was performed in anesthetized adult male SHR.
The right kidney was removed, and left renal artery was subjected to ischemia by clamping for 40 minutes.
The treated group received synthetic superoxide dismutase mimetic TEMPOL in the femoral vein 5 minutes before, during, and 175 minutes after the period of reperfusion, while the control AKI group received the vehicle via the same route.
All parameters were measured 24 h after renal reperfusion.
TEMPOL treatment significantly decreased mean arterial pressure and total peripheral resistance P<0.05 compared to AKI control.
It also increased cardiac output and catalase activity P<0.05.
Lipid peroxidation and renal vascular resistance were decreased in TEMPOL P<0.05.
Plasma creatinine and kidney morphological parameters were unchanged among TEMPOL treated and control groups.
Our study shows that superoxide radicals participate in haemodynamic control, but acute superoxide scavenging is ineffective in glomerular and tubular improvement, probably due to hypertension-induced strong endothelial dysfunction which neutralizes beneficial effects of O2− scavenging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miloradović, Zoran& Ivanov, Milan& Mihailović-Stanojević, Nevena& Grujić Milanović, Jelica& Jovović, Đurđica& Vajić, Una-Jovana…[et al.]. 2014. Acute Superoxide Radical Scavenging Reduces Blood Pressure but Does Not Influence Kidney Function in Hypertensive Rats with Postischemic Kidney Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-477516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miloradović, Zoran…[et al.]. Acute Superoxide Radical Scavenging Reduces Blood Pressure but Does Not Influence Kidney Function in Hypertensive Rats with Postischemic Kidney Injury. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-477516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miloradović, Zoran& Ivanov, Milan& Mihailović-Stanojević, Nevena& Grujić Milanović, Jelica& Jovović, Đurđica& Vajić, Una-Jovana…[et al.]. Acute Superoxide Radical Scavenging Reduces Blood Pressure but Does Not Influence Kidney Function in Hypertensive Rats with Postischemic Kidney Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-477516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر