N-Acetyltransferase 1 (NAT1) Genotype : A Risk Factor for Urinary Bladder Cancer in a Lebanese Population
المؤلفون المشاركون
Dhaini, Hassan R.
Jabbour, Michel E.
Yassine, Ibrahim A.
Kobeissi, Loulou
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In Lebanon, bladder cancer is the second most incident cancer among men.
This study investigates a possible association between N-acetyltransferase 1 (NAT1) genotype, a drug-metabolizing enzyme coding gene, and bladder cancer in Lebanese men.
A case-control study (54 cases and 105 hospital-based controls) was conducted in two major hospitals in Beirut.
Cases were randomly selected from patients diagnosed in the period of 2002–2008.
Controls were conveniently identified and selected from the same settings.
Data was collected using interview questionnaire and blood analysis.
NAT1 genotypes were determined by PCR-RFLP.
Statistical analysis revolved around univariate, bivariate, and multivariate logistic regression models, along with checks for effect modification.
Results showed NAT1∗14A allele, smoking, occupational exposure to combustion fumes, and prostate-related symptoms, to be risk factors for bladder cancer.
The odds of carrying at least one NAT1∗14A allele are 7 times higher in cases compared to controls (OR=7.86, 95% CI: 1.53–40.39).
A gene-environment interaction was identified for NAT1∗14A allele with occupational exposure to combustion fumes.
Among carriers of NAT1∗14A allele, the odds of bladder cancer dropped to 2.03 from 3.72.
Our study suggests NAT1∗14A allele as a possible biomarker for bladder cancer.
Further research is recommended to confirm this association.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yassine, Ibrahim A.& Kobeissi, Loulou& Jabbour, Michel E.& Dhaini, Hassan R.. 2012. N-Acetyltransferase 1 (NAT1) Genotype : A Risk Factor for Urinary Bladder Cancer in a Lebanese Population. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-477565
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yassine, Ibrahim A.…[et al.]. N-Acetyltransferase 1 (NAT1) Genotype : A Risk Factor for Urinary Bladder Cancer in a Lebanese Population. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-477565
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yassine, Ibrahim A.& Kobeissi, Loulou& Jabbour, Michel E.& Dhaini, Hassan R.. N-Acetyltransferase 1 (NAT1) Genotype : A Risk Factor for Urinary Bladder Cancer in a Lebanese Population. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-477565
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477565
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر