Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth : A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease
المؤلفون المشاركون
Pascual, M.
Friedrich, L.
Barbey, F.
Venetz, J.-P.
المصدر
Case Reports in Transplantation
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-13
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Some experimental studies have suggested a beneficial effect of the mammalian target of rapamycin (mTOR) inhibitor use on hepatic and renal cyst growth in patients with autosomal dominant polycystic kidney disease (ADPKD).
However, the results of clinical studies are conflicting and the role of mTOR inhibitors is still uncertain.
We report the case of a patient with ADPKD who underwent deceased kidney transplantation because of an end-stage renal disease.
The evolution was uneventful with an excellent graft function under cyclosporine (CsA) monotherapy.
Some years later, the patient developed a symptomatic hepatomegaly due to growth of cysts.
CsA was replaced by sirolimus, an mTOR inhibitor, in order to reduce or control the increase in the cyst and liver volume.
Despite the switch, the hepatic volume increased by 25% in two years.
Finally sirolimus was stopped because of the lack of effect on hepatic cyst growth and the presence of sirolimus side effects.
The interest of our case resides in the followup by MRI imaging during the mTOR inhibitor treatment and 15 months after the restart of the initial immunosuppressive therapy.
This observation indicates that mTOR inhibitors did not have significant effect on cyst-associated hepatic growth in our patient, which is consistent with some results of recent large clinical studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Friedrich, L.& Barbey, F.& Pascual, M.& Venetz, J.-P.. 2012. Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth : A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-477568
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Friedrich, L.…[et al.]. Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth : A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-477568
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Friedrich, L.& Barbey, F.& Pascual, M.& Venetz, J.-P.. Absence of mTOR Inhibitor Effect on Hepatic Cyst Growth : A Case Report of a Kidney Transplant Recipient with Autosomal Dominant Polycystic Kidney Disease. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-477568
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477568
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر