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Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells
المؤلفون المشاركون
Jian, Jiun-Yu
Lin, Yi-Feng
Wang, Chien-Kai
Chang, Chun-Chao
Lin, Chi-Shian
Chang, Yu-Jia
Tai, Chen-Jei
Tai, Cheng-Jeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Colorectal cancer is a common cancer worldwide, and chemotherapy is a mainstream approach for advanced and recurrent cases.
Development of effective complementary drugs could help improve tumor suppression efficiency and control adverse effects from chemotherapy.
The aqueous extract of Solanum nigrum leaves (AE-SN) is an essential component in many traditional Chinese medicine formulas for treating cancer, but there is a lack of evidence verifying its tumor suppression efficacy in colorectal cancer.
The purpose of this study is to evaluate the tumor suppression efficacy of AE-SN using DLD-1 and HT-29 human colorectal carcinoma cells and examine the combined drug effect when combined with the chemotherapeutic drugs cisplatin, doxorubicin, docetaxel, and 5-fluorouracil.
The results indicated that AE-SN induced autophagy via microtubule-associated protein 1 light chain 3 A/B II accumulation but not caspase-3-dependent apoptosis in both cell lines.
The IC50s after 48 hours of treatment were 0.541 and 0.948 mg/ml AE-SN in DLD-1 and HT-29, respectively.
AE-SN also demonstrated a combined drug effect with all tested drugs by enhancing cytotoxicity in tumor cells.
Our results suggest that AE-SN has potential in the development of complementary chemotherapy for colorectal cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tai, Chen-Jei& Wang, Chien-Kai& Tai, Cheng-Jeng& Lin, Yi-Feng& Lin, Chi-Shian& Jian, Jiun-Yu…[et al.]. 2013. Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477727
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tai, Chen-Jei…[et al.]. Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-477727
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tai, Chen-Jei& Wang, Chien-Kai& Tai, Cheng-Jeng& Lin, Yi-Feng& Lin, Chi-Shian& Jian, Jiun-Yu…[et al.]. Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-477727
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477727
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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