Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA
المؤلفون المشاركون
Guin, Partha Sarathi
Das, Saurabh
المصدر
International Journal of Electrochemistry
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Electrochemical behavior of the anticancer drug doxorubicin hydrochloride was studied using cyclic voltammetry in aqueous medium using Hepes buffer (pH~7.4).
At this pH, doxorubicin hydrochloride undergoes a reversible two-electron reduction with E1/2 value −665±5 mV (versus Ag/AgCl, saturated KCl).
Depending on scan rates, processes were either quasireversible (at low scan rates) or near perfect reversible (at high scan rates).
This difference in behavior of doxorubicin hydrochloride with scan rate studied over the same potential range speaks of differences in electron transfer processes in doxorubicin hydrochloride.
Attempt was made to identify and understand the species involved using simulation.
The information obtained was used to study the interaction of doxorubicin hydrochloride with calf thymus DNA.
Cathodic peak current gradually decreased as more calf thymus DNA was added.
The decrease in cathodic peak current was used to estimate the interaction of the drug with calf thymus DNA.
Nonlinear curve fit analysis was applied to evaluate the intrinsic binding constant and site size of interaction that was compared with previous results on doxorubicin hydrochloride-DNA interaction monitored by cyclic voltammetry or spectroscopic techniques.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guin, Partha Sarathi& Das, Saurabh. 2014. Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA. International Journal of Electrochemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-477970
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guin, Partha Sarathi& Das, Saurabh. Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA. International Journal of Electrochemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-477970
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guin, Partha Sarathi& Das, Saurabh. Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA. International Journal of Electrochemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-477970
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-477970
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر