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Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling
المؤلفون المشاركون
Tsao, Po-Hung
Yu, Chao Yuan
Jhan, Jie-Yu
Chen, Yi-Lin Sophia
Lee, Po-Lei
Chan, De-Chuan
Su, Kang-Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Gastric cancer is one of the most common malignant cancers due to poor prognoses and high mortality rates worldwide.
However, an effective chemotherapeutic drug without side effects remains lacking.
Saussurea involucrata (SI) Kar.
et Kir., also known as snow lotus, grows in mountainous rocky habitats at 2600 m elevation in the Tian Shan and A’er Tai regions of China.
The ethyl acetate extract of SI had been shown to inhibit proliferation and induce apoptosis in various tumor cells.
In this study, we demonstrated that Hispidulin, active ingredients in SI, inhibits the growth of AGS gastric cancer cells.
After Hispidulin treatment, NAG-1 remained highly expressed, whereas COX-2 expression was downregulated.
Flow cytometric analysis indicated that Hispidulin induces G1/S phase arrest and apoptosis in time- and concentration-dependent manners.
G1/S arrest correlated with upregulated p21/WAF1 and p16 and downregulated cyclin D1 and cyclin E, independent of p53 pathway.
In addition, Hispidulin can elevate Egr-1 expression and ERK1/2 activity, whereas ERK1/2 inhibitor markedly attenuated NAG-1 mediated apoptosis.
Taken together, Hispidulin can efficiently activate ERK1/2 signaling followed by NAG-1 constitutive expression and trigger cell cycle arrest as well as apoptosis in cancer cell.
It can be a potential compound for combination therapy of gastric cancer in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Chao Yuan& Su, Kang-Yi& Lee, Po-Lei& Jhan, Jie-Yu& Tsao, Po-Hung& Chan, De-Chuan…[et al.]. 2013. Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478065
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Chao Yuan…[et al.]. Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-478065
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Chao Yuan& Su, Kang-Yi& Lee, Po-Lei& Jhan, Jie-Yu& Tsao, Po-Hung& Chan, De-Chuan…[et al.]. Potential Therapeutic Role of Hispidulin in Gastric Cancer through Induction of Apoptosis via NAG-1 Signaling. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-478065
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478065
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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