Suppression of Aldosterone Synthesis and Secretion by Ca2+ Channel Antagonists
المؤلفون المشاركون
Isaka, Tsuyoshi
Ikeda, Keiichi
Fujioka, Kouki
Tojo, Katsuyoshi
Manome, Yoshinobu
المصدر
International Journal of Endocrinology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aldosterone, a specific mineralocorticoid receptor (MR) agonist and a key player in the development of hypertension, is synthesized as a final product of renin-angiotensin-aldosterone system.
Hypertension can be generally treated by negating the effects of angiotensin II through the use of angiotensin-converting enzyme inhibitors (ACE-Is) or angiotensin II type 1 receptor antagonists (ARBs).
However, the efficacy of angiotensin II blockade by such drugs is sometimes diminished by the so-called “aldosterone breakthrough” effect, by which ACE-Is or ARBs (renin-angiotensin system (RAS) inhibitors) gradually lose their effectiveness against hypertension due to the overproduction of aldosterone, known as primary aldosteronism.
Although MR antagonists are used to antagonize the effects of aldosterone, these drugs may, however, give rise to life-threatening adverse actions, such as hyperkalemia, particularly when used in conjunction with RAS inhibitors.
Recently, several groups have reported that some dihydropyridine Ca2+ channel blockers (CCBs) have inhibitory actions on aldosterone production in in vitro and in the clinical setting.
Therefore, the use of such dihydropyridine CCBs to treat aldosterone-related hypertension may prove beneficial to circumvent such therapeutic problems.
In this paper, we discuss the mechanism of action of CCBs on aldosterone production and clinical perspectives for CCB use to inhibit MR activity in hypertensive patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ikeda, Keiichi& Isaka, Tsuyoshi& Fujioka, Kouki& Manome, Yoshinobu& Tojo, Katsuyoshi. 2012. Suppression of Aldosterone Synthesis and Secretion by Ca2+ Channel Antagonists. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-478169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ikeda, Keiichi…[et al.]. Suppression of Aldosterone Synthesis and Secretion by Ca2+ Channel Antagonists. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-478169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ikeda, Keiichi& Isaka, Tsuyoshi& Fujioka, Kouki& Manome, Yoshinobu& Tojo, Katsuyoshi. Suppression of Aldosterone Synthesis and Secretion by Ca2+ Channel Antagonists. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-478169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر