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An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress
المؤلفون المشاركون
Wang, Qiujuan
Shen, Pingniang
Lin, Zhihong
Zhu, Danni
Yan, Yongqing
Yu, Boyang
Ruan, Kefeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Oxidative stress is involved in the pathogenesis of ischemic neuronal injury.
A Chinese herbal formula composed of Poria cocos (Chinese name: Fu Ling), Atractylodes macrocephala (Chinese name: Bai Zhu) and Angelica sinensis (Chinese names: Danggui, Dong quai, Donggui; Korean name: Danggwi) (FBD), has been proved to be beneficial in the treatment of cerebral ischemia/reperfusion (I/R).This study was carried out to evaluate the protective effect of FBD against neuronal oxidative stress in vivo and in vitro.
Rat I/R were established by middle cerebral artery occlusion (MCAO) for 1 h, followed by 24 h reperfusion.
MCAO led to significant depletion in superoxide dismutase and glutathione and rise in lipid peroxidation (LPO) and nitric oxide in brain.
The neurological deficit and brain infarction were also significantly elevated by MCAO as compared with sham-operated group.
All the brain oxidative stress and damage were significantly attenuated by 7 days pretreatment with the aqueous extract of FBD (250 mg kg−1, p.o.).
Moreover, cerebrospinal fluid sampled from FBD-pretreated rats protected PC12 cells against oxidative insult induced by 0.2 mM hydrogen peroxide, in a concentration and time-dependent manner (IC50 10.6%, ET50 1.2 h).
However, aqueous extract of FBD just slightly scavenged superoxide anion radical generated in xanthine–xanthine oxidase system (IC50 2.4 mg ml−1) and hydroxyl radical generated in Fenton reaction system (IC50 3.6 mg ml−1).
In conclusion, FBD was a distinct antioxidant phytotherapy to rescue neuronal oxidative stress, through blocking LPO, restoring endogenous antioxidant system, but not scavenging free radicals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Zhihong& Zhu, Danni& Yan, Yongqing& Yu, Boyang& Wang, Qiujuan& Shen, Pingniang…[et al.]. 2011. An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Zhihong…[et al.]. An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-478177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Zhihong& Zhu, Danni& Yan, Yongqing& Yu, Boyang& Wang, Qiujuan& Shen, Pingniang…[et al.]. An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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