Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression : Double-Blind, Randomized Non-Inferiority Trial
المؤلفون المشاركون
Padula, A. E.
Calil, H. M.
Molina, A.
Adler, U. C.
Paiva, N. M. P.
Adler, M. S.
Cesar, A. T.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Homeopathy is a complementary and integrative medicine used in depression, The aim of this study is to investigate the non-inferiority and tolerability of individualized homeopathic medicines [Quinquagintamillesmial (Q-potencies)] in acute depression, using fluoxetine as active control.
Ninety-one outpatients with moderate to severe depression were assigned to receive an individualized homeopathic medicine or fluoxetine 20 mg day−1 (up to 40 mg day−1) in a prospective, randomized, double-blind double-dummy 8-week, single-center trial.
Primary efficacy measure was the analysis of the mean change in the Montgomery & Åsberg Depression Rating Scale (MADRS) depression scores, using a non-inferiority test with margin of 1.45.
Secondary efficacy outcomes were response and remission rates.
Tolerability was assessed with the side effect rating scale of the Scandinavian Society of Psychopharmacology.
Mean MADRS scores differences were not significant at the 4th (P = .654) and 8th weeks (P = .965) of treatment.
Non-inferiority of homeopathy was indicated because the upper limit of the confidence interval (CI) for mean difference in MADRS change was less than the non-inferiority margin: mean differences (homeopathy-fluoxetine) were −3.04 (95% CI −6.95, 0.86) and −2.4 (95% CI −6.05, 0.77) at 4th and 8th week, respectively.
There were no significant differences between the percentages of response or remission rates in both groups.
Tolerability: there were no significant differences between the side effects rates, although a higher percentage of patients treated with fluoxetine reported troublesome side effects and there was a trend toward greater treatment interruption for adverse effects in the fluoxetine group.
This study illustrates the feasibility of randomized controlled double-blind trials of homeopathy in depression and indicates the non-inferiority of individualized homeopathic Q-potencies as compared to fluoxetine in acute treatment of outpatients with moderate to severe depression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adler, U. C.& Paiva, N. M. P.& Cesar, A. T.& Adler, M. S.& Molina, A.& Padula, A. E.…[et al.]. 2011. Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression : Double-Blind, Randomized Non-Inferiority Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478231
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adler, U. C.…[et al.]. Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression : Double-Blind, Randomized Non-Inferiority Trial. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-478231
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adler, U. C.& Paiva, N. M. P.& Cesar, A. T.& Adler, M. S.& Molina, A.& Padula, A. E.…[et al.]. Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression : Double-Blind, Randomized Non-Inferiority Trial. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-478231
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478231
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر