Identification of IbeR as a Stationary-Phase Regulator in Meningitic Escherichia coli K1 that Carries a Loss-of-Function Mutation in rpoS
المؤلفون المشاركون
Chi, Feng
Huang, Sheng-He
Gallaher, Timothy K.
Wu, Chun-Hua
Jong, Ambrose
Wang, Ying
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-03-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
IbeR is a regulator present in meningitic Escherichia coli strain E44 that carries a loss-of-function mutation in the stationary-phase (SP) regulatory gene rpoS.
In order to determine whether IbeR is an SP regulator in E44, two-dimensional gel electrophoresis and LC-MS were used to compare the proteomes of a noninvasive ibeR deletion mutant BR2 and its parent strain E44 in the SP.
Four up-regulated (TufB, GapA, OmpA, AhpC) and three down-regulated (LpdA, TnaA, OpmC) proteins in BR2 were identified when compared to E44.
All these proteins contribute to energy metabolism or stress resistance, which is related to SP regulation.
One of the down-regulated proteins, tryptophanase (TnaA), which is regulated by RpoS in other E.
coli strains, is associated with SP regulation via production of a signal molecule indole.
Our studies demonstrated that TnaA was required for E44 invasion, and that indole was able to restore the noninvasive phenotype of the tnaA mutant.
The production of indole was significantly reduced in BR2, indicating that ibeR is required for the indole production via tnaA.
Survival studies under different stress conditions indicated that IbeR contributed to bacteria stress resistance in the SP.
Taken together, IbeR is a novel regulator contributing to the SP regulation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chi, Feng& Wang, Ying& Gallaher, Timothy K.& Wu, Chun-Hua& Jong, Ambrose& Huang, Sheng-He. 2009. Identification of IbeR as a Stationary-Phase Regulator in Meningitic Escherichia coli K1 that Carries a Loss-of-Function Mutation in rpoS. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-478244
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chi, Feng…[et al.]. Identification of IbeR as a Stationary-Phase Regulator in Meningitic Escherichia coli K1 that Carries a Loss-of-Function Mutation in rpoS. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-13.
https://search.emarefa.net/detail/BIM-478244
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chi, Feng& Wang, Ying& Gallaher, Timothy K.& Wu, Chun-Hua& Jong, Ambrose& Huang, Sheng-He. Identification of IbeR as a Stationary-Phase Regulator in Meningitic Escherichia coli K1 that Carries a Loss-of-Function Mutation in rpoS. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-13.
https://search.emarefa.net/detail/BIM-478244
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478244
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر