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Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients
المؤلفون المشاركون
Loukas, Alex
Cardoso, Luciana Santos
de Goes, Alfredo Miranda
Carvalho, Edgar M.
Araujo, Maria Ilma
Oliveira, Sérgio Costa
Oliveira, Ricardo Riccio
Bafica, Aline Michelle Barbosa
المصدر
Journal of Parasitology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High levels of proinflammatory cytokines such as IFN-γ and TNF are associated with tissue lesions in cutaneous leishmaniasis (CL).
We previously demonstrated that Schistosoma mansoni antigens downmodulate the in vitro cytokine response in CL.
In the current study we evaluated whether S.
mansoni antigens alter monocyte and T-lymphocyte phenotypes in leishmaniasis.
Peripheral blood mononuclear cells of CL patients were cultured with L.
braziliensis antigen in the presence or absence of the S.
mansoni antigens rSm29, rSmTSP-2- and PIII.
Cells were stained with fluorochrome conjugated antibodies and analyzed by flow cytometry.
The addition of rSm29 to the cultures decreased the expression of HLA-DR in nonclassical (CD14+CD16++) monocytes, while the addition of PIII diminished the expression of this molecule in classical (CD14++CD16-) and intermediate (CD14++CD16+) monocytes.
The addition of PIII and rSmTSP-2 resulted in downmodulation of CD80 expression in nonclassical and CD86 expression in intermediate monocytes, respectively.
These two antigens increased the expression of CTLA-4 in CD4+ T cells and they also expanded the frequency of CD4+CD25highFoxp3+ T cells.
Taken together, we show that S.
mansoni antigens, mainly rSmTSP-2 and PIII, are able to decrease the activation status of monocytes and also to upregulate the expression of modulatory molecules in T lymphocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bafica, Aline Michelle Barbosa& Cardoso, Luciana Santos& Oliveira, Sérgio Costa& Loukas, Alex& de Goes, Alfredo Miranda& Oliveira, Ricardo Riccio…[et al.]. 2012. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-478251
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bafica, Aline Michelle Barbosa…[et al.]. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-478251
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bafica, Aline Michelle Barbosa& Cardoso, Luciana Santos& Oliveira, Sérgio Costa& Loukas, Alex& de Goes, Alfredo Miranda& Oliveira, Ricardo Riccio…[et al.]. Changes in T-Cell and Monocyte Phenotypes In Vitro by Schistosoma mansoni Antigens in Cutaneous Leishmaniasis Patients. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-478251
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478251
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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