Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice
المؤلفون المشاركون
da Silva, Andréa Cristina Apolinário
Pitta, Ivan da Rocha
Albuquerque, Mônica Camelo Pessoa de Azevedo
Irmão, João Inácio
Neves, Juliana Kelle de Andrade Lemoine
de Medeiros, Paloma Lys
da Silva, Eliete Cavalcanti
Souza, Valdênia Maria Oliveira
de Lima, Maria do Carmo Alves
Costa, Vláudia Maria Assis
Galdino, Suely Lins
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Previous studies conducted with the imidazolidinic derivative 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one (LPSF-PT05) show outstanding activity against adult Schistosoma mansoni worms in vitro.
In the first phase of this study, S.
mansoni-infected mice were treated, orally, with 100 mg/Kg of the LPSF-PT05 in three formulations: Tween 80 and saline solution, oil/water (70 : 30) emulsion, and solid dispersion with polyethylene glycol (PEG).
In the second phase, three other doses of the LPSF-PT05 in PEG were tested: 3, 10, 30 mg/kg.
These treatment regimens significantly reduced the number of recovered worms due to increases in the solubility of the compound in this formulation; the greatest reduction (70.5%) was observed at the dose of 100 mg/kg.
There was no changes in the pattern of mature egg compared to immature eggs; however there was a significant increase in the number of dead eggs.
Histopathological analysis of liver tissue showed changes in morphological aspects of the hepatic parenchyma with decrease exudative-productive hepatic granuloma stages, although we found no significant differences in IFN-γ, IL-4, IL-10, or NO production in response to the specific antigen SEA.
The results show the derivative LPSF-PT05 to be a potential candidate in the etiological treatment of schistosomiasis with a possible dampening effect of the granulomatous process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
da Silva, Andréa Cristina Apolinário& Neves, Juliana Kelle de Andrade Lemoine& Irmão, João Inácio& Costa, Vláudia Maria Assis& Souza, Valdênia Maria Oliveira& de Medeiros, Paloma Lys…[et al.]. 2012. Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
da Silva, Andréa Cristina Apolinário…[et al.]. Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-478267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
da Silva, Andréa Cristina Apolinário& Neves, Juliana Kelle de Andrade Lemoine& Irmão, João Inácio& Costa, Vláudia Maria Assis& Souza, Valdênia Maria Oliveira& de Medeiros, Paloma Lys…[et al.]. Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-478267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر