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A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane
المؤلفون المشاركون
Kobayashi, Toshimitsu
Horii, Akira
Shiga, Kiyoto
Ogawa, Takenori
Sunamura, Makoto
Saiki, Yuriko
المصدر
International Journal of Otolaryngology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-20
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Recently, an inverse relationship between resistance to platinum-based chemotherapeutic agents and taxanes has been implicated in breast and ovarian cancers, and a possible pivotal role for BRCA1 has also been suggested.
Because cis-diamminedichloroplatinum (CDDP) and taxanes are the most active antitumor agents against head and neck squamous cell carcinoma (HNSCC), we analyzed the sensitivity of nine HNSCC cell lines and their previously established derived CDDP-resistant cell lines to two representative taxanes: docetaxel and paclitaxel.
None of the nine original cell lines showed any cross resistance between CDDP and taxanes, but one of the CDDP-resistant cell lines, RPMI2650CR, demonstrated hypersensitivity to both taxanes when compared to the parental cell line, RPMI2650.
Furthermore, RPMI2650CR exhibited increased expression of BRCA1.
These data suggest that (i) taxanes are a good candidate for a second-line therapeutic drug for HNSCC patients with acquired CDDP resistance and (ii) BRCA1 can be a candidate marker for predicting an inverse CDDP/taxane sensitivity phenotype in HNSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saiki, Yuriko& Ogawa, Takenori& Shiga, Kiyoto& Sunamura, Makoto& Kobayashi, Toshimitsu& Horii, Akira. 2011. A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane. International Journal of Otolaryngology،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-478383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saiki, Yuriko…[et al.]. A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane. International Journal of Otolaryngology No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-478383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saiki, Yuriko& Ogawa, Takenori& Shiga, Kiyoto& Sunamura, Makoto& Kobayashi, Toshimitsu& Horii, Akira. A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane. International Journal of Otolaryngology. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-478383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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