Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice
المؤلفون المشاركون
He, Shan-An
Dong, Di
Yu, Hong
Wu, Lin-Hua
Xu, Zeng-Lai
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was carried out to evaluate the protective effect of anthocyanins extract of blueberry on trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease (IBD) model of mice.
The study employed female C57BL/6 mice (n = 50), and colitis was induced by intracolonic injection of 0.5 mg of TNBS dissolved in 50% ethanol–phosphate buffered solution.
The mice were divided into five groups (n = 10): vehicle, TNBS control and anthocyanins groups that received different doses of anthocyanins extract (10, 20 and 40 mg kg-1) daily for 6 days.
Both increase in body weight and diarrhea symptoms were monitored each day.
After 6 days, the animals were killed, and the following parameters were assessed: colon length, morphological score, histological score and biochemical assay (NO, myeloperoxidase (MPO), interleukin (IL)-12, IL-10, tumor necrosis factor (TNF)-α and interferon (IFN)-γ).
The results showed that the anthocyanins extract of blueberry rendered strong protection against TNBS-induced colonic damage at a dosage of 40 mg kg-1.
When compared with the control, anthocyanins extract significantly prevented loss of body weight and ameliorated the scores of diarrhea, morphology and histology.
Treatment with anthocyanins extract restored IL-10 excretion, as well as caused reduction in the levels of NO, MPO, IL-12, TNF-α and IFN-γ.
Our research revealed the protective effect of anthocyanins extract from blueberry on TNBS-induced experimental colitis in mice, as well as examined whether high levels of dietary blueberries would lower the risk or have protective effects on human IBD, which may require further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Lin-Hua& Xu, Zeng-Lai& Dong, Di& He, Shan-An& Yu, Hong. 2011. Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478636
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Lin-Hua…[et al.]. Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-478636
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Lin-Hua& Xu, Zeng-Lai& Dong, Di& He, Shan-An& Yu, Hong. Protective Effect of Anthocyanins Extract from Blueberry on TNBS-Induced IBD Model of Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-478636
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478636
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر