Cellular Response to a Novel Fetal Acellular Collagen Matrix : Implications for Tissue Regeneration
المؤلفون المشاركون
Garg, Ravi K.
Rennert, Robert C.
Sorkin, Michael
Gurtner, Geoffrey C.
Januszyk, Michael
المصدر
International Journal of Biomaterials
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
PriMatrix (TEI Biosciences Inc., Boston, MA, USA) is a novel acellular collagen matrix derived from fetal bovine dermis that is designed for use in partial- and full-thickness wounds.
This study analyzes the cellular response to PriMatrix in vivo, as well as the ability of this matrix to facilitate normal tissue regeneration.
Methods.
Five by five mm squares of rehydrated PriMatrix were implanted in a subcutaneous fashion on the dorsum of wild-type mice.
Implant site tissue was harvested for histology, immunohistochemistry (IHC), and flow cytometric analyses at multiple time points until day 28.
Results.
PriMatrix implants were found to go through a biological progression initiated by a transient infiltrate of inflammatory cells, followed by mesenchymal cell recruitment and vascular development.
IHC analysis revealed that the majority of the implanted fetal dermal collagen fibers persisted through day 28 but underwent remodeling and cellular repopulation to form tissue with a density and morphology consistent with healthy dermis.
Conclusions.
PriMatrix implants undergo progressive in vivo remodeling, facilitating the regeneration of histologically normal tissue through a mild inflammatory and progenitor cell response.
Regeneration of normal tissue is especially important in a wound environment, and these findings warrant further investigation of PriMatrix in this setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rennert, Robert C.& Sorkin, Michael& Garg, Ravi K.& Januszyk, Michael& Gurtner, Geoffrey C.. 2013. Cellular Response to a Novel Fetal Acellular Collagen Matrix : Implications for Tissue Regeneration. International Journal of Biomaterials،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478842
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rennert, Robert C.…[et al.]. Cellular Response to a Novel Fetal Acellular Collagen Matrix : Implications for Tissue Regeneration. International Journal of Biomaterials No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-478842
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rennert, Robert C.& Sorkin, Michael& Garg, Ravi K.& Januszyk, Michael& Gurtner, Geoffrey C.. Cellular Response to a Novel Fetal Acellular Collagen Matrix : Implications for Tissue Regeneration. International Journal of Biomaterials. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-478842
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-478842
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر