Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population : Exclusion of Ineligible Candidates for Adjuvant Chemotherapy

المؤلفون المشاركون

He, Zhisong
Zhang, Lei
Zhang, Qifu
Zhou, Liqun
Chen, Xiaopeng
Qian, Cheng
Li, Xuesong
Yu, Wei
Fang, Dong
Zhang, Xiaoyu
Xiong, Gengyan

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-08-10

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Objectives.

To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC).

Methods.

We retrospectively analyzed 606 consecutive Chinese UTUC patients treated by RNU from 2000 to 2010.

We chose an eGFR of 60 and 45 ml/min/1.73 m2 as cut-offs for full-dose and reduced-dose AC eligibility.

Results.

Median eGFR for all patients before and after surgery was 64 and 49 ml/min/1.73 m2 (P<0.001).

The proportion of patients ineligible to receive full-dose and reduced-dose AC changed from 42% to 74% and from 20% to 38.1%.

Older age (OR = 1.007), preoperative eGFR (OR = 0.993), absence of hydronephrosis (OR = 0.801), smaller tumor size (OR = 0.962), and tumor without multifocality (OR = 0.876) were predictive for ineligibility for full-dose AC.

Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC.

The c-index of the two models was 0.757 and 0.836.

Postoperative renal function was not associated with worse survival.

Conclusions.

Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fang, Dong& Zhang, Qifu& Li, Xuesong& Qian, Cheng& Xiong, Gengyan& Zhang, Lei…[et al.]. 2014. Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population : Exclusion of Ineligible Candidates for Adjuvant Chemotherapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478978

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fang, Dong…[et al.]. Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population : Exclusion of Ineligible Candidates for Adjuvant Chemotherapy. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-478978

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fang, Dong& Zhang, Qifu& Li, Xuesong& Qian, Cheng& Xiong, Gengyan& Zhang, Lei…[et al.]. Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population : Exclusion of Ineligible Candidates for Adjuvant Chemotherapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-478978

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-478978