Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas
المؤلفون المشاركون
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex.
In previous research, we found that auditory cortical tuning and tonotopy were impaired by cross-modal invasion of visual inputs.
Sensory deprivation is typically associated with a loss of inhibition.
To determine whether inhibitory plasticity is responsible for this process, we measured pre- and postsynaptic changes in inhibitory connectivity in ferret auditory cortex (AC) after cross-modal plasticity.
We found that blocking GABAA receptors increased responsiveness and broadened sound frequency tuning in the cross-modal group more than in the normal group.
Furthermore, expression levels of glutamic acid decarboxylase (GAD) protein were increased in the cross-modal group.
We also found that blocking inhibition unmasked visual responses of some auditory neurons in cross-modal AC.
Overall, our data suggest a role for increased inhibition in reducing the effectiveness of the abnormal visual inputs and argue that decreased inhibition is not responsible for compromised auditory cortical function after cross-modal invasion.
Our findings imply that inhibitory plasticity may play a role in reorganizing sensory cortex after cross-modal invasion, suggesting clinical strategies for recovery after brain injury or sensory deprivation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mao, Yu-Ting& Pallas, Sarah L.. 2013. Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas. Neural Plasticity،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-479105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mao, Yu-Ting& Pallas, Sarah L.. Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas. Neural Plasticity No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-479105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mao, Yu-Ting& Pallas, Sarah L.. Cross-Modal Plasticity Results in Increased Inhibition in Primary Auditory Cortical Areas. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-479105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر