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Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration
المؤلفون المشاركون
Koutroumanidou, Eleni
Charalabopoulos, Konstantinos
Pagonopoulou, Olga
Bezirtzoglou, Eugenia
Kortsaris, Alexandros
Polissiou, Moschos
Kimbaris, Athanasios
المصدر
Epilepsy Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The effect of pretreatment with essential oils (EOs) from eight aromatic plants on the seizure latency and severity of pentylenetetrazol- (PTZ-) induced seizures in mice was evaluated.
Weight-dependent doses of Rosmarinus officinalis, Ocimum basilicum, Mentha spicata, Mentha pulegium, Lavandula angustifolia, Mentha piperita, Origanum dictamnus, and Origanum vulgare, isolated from the respective aromatic plants from NE Greece, were administered 60 minutes prior to intraperitoneal (i.p.) injection of a lethal dose of PTZ to eight respective groups of Balb-c mice.
Control group received only one i.p.
PTZ injection.
Motor and behavioral activity of the animals after EOs administration, development of tonic-clonic seizures, seizure latency and severity, and percentage of survival after PTZ administration were determined for each group.
All groups of mice treated with the EOs showed reduced activity and stability after the administration of the oil, except for those treated with O.
vulgare (100% mortality after the administration of the oil).
After PTZ administration, mice from the different groups showed increased latency and reduced severity of seizures (ranging from simple twitches to complete seizures).
Mice who had received M.
piperita demonstrated no seizures and 100% survival.
The different drastic component and its concentration could account for the diversity of anticonvulsant effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koutroumanidou, Eleni& Kimbaris, Athanasios& Kortsaris, Alexandros& Bezirtzoglou, Eugenia& Polissiou, Moschos& Charalabopoulos, Konstantinos…[et al.]. 2013. Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration. Epilepsy Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koutroumanidou, Eleni…[et al.]. Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration. Epilepsy Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-479283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koutroumanidou, Eleni& Kimbaris, Athanasios& Kortsaris, Alexandros& Bezirtzoglou, Eugenia& Polissiou, Moschos& Charalabopoulos, Konstantinos…[et al.]. Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-Induced Seizures in Mice after Essential Oil Administration. Epilepsy Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-479283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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