Mathematical Modeling of Melanoma Cell Migration with an Elastic Continuum Model for the Evaluation of the Influence of Tumor Necrosis Factor-Alpha on Migration
المؤلفون المشاركون
Mendes de Azevedo, Fernando
Hisayasu Suzuki, Daniela Ota
de Godoy Marques, Claudia Mirian
Vianna Gallinaro, Julia
المصدر
Journal of Computational Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
An elastic continuum mathematical model was implemented to study collective C8161 melanoma cell migration during a “scratch wound” assay, in control and under the influence of the proinflammatory cytokine tumour necrosis factor-alpha (TNF-α).
The model has four constants: force that results from lamellipod formation (F), adhesion constant between cells and extracellular matrix (ECM) (b), cell layer elasticity modulus (k), and growth rate (ρ).
A nonlinear regression routine was used to obtain the parameters of the model with data from an experiment made with C8161 melanoma cells, with and without TNF-α.
Coefficient of determination for both situations was R2=0.89 and R2=0.92, respectively.
The parameters values obtained were similar to the ones found in the literature.
However, the adhesion constant value decreased with the introduction of TNF-α, which is not in accordance with expected since the presence of TNF-α is associated with an increased expression of integrins that would promote an enhanced adhesion among cells.
The model was used in a study relating to the adhesion constant and cell migration, and the results suggested that cell migration decreases with higher adhesion, which is also not in accordance with expected.
These differences would not occur if it was considered that TNF-α increases the elasticity modulus of the cell layer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vianna Gallinaro, Julia& de Godoy Marques, Claudia Mirian& Mendes de Azevedo, Fernando& Hisayasu Suzuki, Daniela Ota. 2013. Mathematical Modeling of Melanoma Cell Migration with an Elastic Continuum Model for the Evaluation of the Influence of Tumor Necrosis Factor-Alpha on Migration. Journal of Computational Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-479322
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vianna Gallinaro, Julia…[et al.]. Mathematical Modeling of Melanoma Cell Migration with an Elastic Continuum Model for the Evaluation of the Influence of Tumor Necrosis Factor-Alpha on Migration. Journal of Computational Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-479322
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vianna Gallinaro, Julia& de Godoy Marques, Claudia Mirian& Mendes de Azevedo, Fernando& Hisayasu Suzuki, Daniela Ota. Mathematical Modeling of Melanoma Cell Migration with an Elastic Continuum Model for the Evaluation of the Influence of Tumor Necrosis Factor-Alpha on Migration. Journal of Computational Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-479322
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479322
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر