Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population : Results from the NORA Study
المؤلفون المشاركون
Pronzato, P.
Di Costanzo, F.
Rulli, E.
Mustacchi, G.
Cazzaniga, M. E.
De Matteis, A.
Floriani, I.
المصدر
International Journal of Breast Cancer
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The present paper described the biological characteristics and clinical behavior of young women in the cohort NORA study Patients and Methods.
From 2000–2002, patients (N>3500) were enrolled at 77 Italian hospitals.
Women aged ≤50 years (N=1013) were stratified into age groups (≤35, 36–40, 41–45, and 46–50 years).
The relationship between age and patient characteristics, cancer presentation, and treatment was analyzed.
Results.
Younger women more frequently had tumors with ER/PgR-negative(χ2=7.07; P=.008), HER2 amplification (χ2=5.76; P=.01), and high (≥10%) Ki67 labelling index (χ2=9.53; P=.002).
Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (P<.0001).
At univariate analysis, ER-ve status, chemotherapy and age resulted as the only statistically significant variables (HR=2.02, P=.004, and >40 versus ≤40, P<.0001, resp.).
At multivariate analysis, after adjustment for significant clinical and pathological factors, age remains a significant prognostic variable (HR=0.93, P=.0021).
Conclusion.
This cohort study suggests that age per sè is an important prognostic factor.
The restricted role of early diagnosis and the aggressive behavior of cancer in this population make necessary the application of targeted medical strategies crucial.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pronzato, P.& Mustacchi, G.& De Matteis, A.& Di Costanzo, F.& Rulli, E.& Floriani, I.…[et al.]. 2010. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population : Results from the NORA Study. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pronzato, P.…[et al.]. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population : Results from the NORA Study. International Journal of Breast Cancer No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-479344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pronzato, P.& Mustacchi, G.& De Matteis, A.& Di Costanzo, F.& Rulli, E.& Floriani, I.…[et al.]. Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population : Results from the NORA Study. International Journal of Breast Cancer. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-479344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر