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Isoliquiritigenin-Induced Differentiation in Mouse Melanoma B16F0 Cell Line
المؤلفون المشاركون
Wang, Zhenhua
Zhao, Hong
Yuan, Xuan
Wang, Yanming
Zhang, Bo
Zheng, Qiusheng
Yang, Fan
Liu, Liangliang
Chen, Xiaoyu
Liu, Jinglei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
The chemotherapeutical treatment is very limited for malignant melanoma, a highly lethal disease occurs globally.
Natural products derived from traditional Chinese medicine licorice are attractive in quest new treatments due to their anti-tumor activities.
A new dietary flavonoid isoliquiritigenin (ISL) were thus investigated to indentify its anti-melanoma activities on mouse melanoma B16F0 cells in present study.
Using biochemical and free radical biological experiments in vitro, we identified the pro-differentiated profiles of ISL and evaluated the role of reactive oxygen species (ROS) during B16F0 cell differentiation.
The data showed a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis.
The accumulated intercellular ROS during exposure are necessary to support ISL-induced differentiation, which was proven by additional redox modulators.
It was confirmed further by the relative activities of enzymes and genes modulated melanogenesis in ISL-treatments with or without ROS modulators.
The tumorigenicity of ISL-treated cells was limited significantly by using the colony formation assay in vitro and an animal model assay in vivo respectively.
Our research demonstrated that isoliquiritigenin is a differentiation-inducing agent, and its mechanisms involve ROS accumulation facilitating melanogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Xiaoyu& Zhang, Bo& Yuan, Xuan& Yang, Fan& Liu, Jinglei& Zhao, Hong…[et al.]. 2012. Isoliquiritigenin-Induced Differentiation in Mouse Melanoma B16F0 Cell Line. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479402
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Xiaoyu…[et al.]. Isoliquiritigenin-Induced Differentiation in Mouse Melanoma B16F0 Cell Line. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-479402
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Xiaoyu& Zhang, Bo& Yuan, Xuan& Yang, Fan& Liu, Jinglei& Zhao, Hong…[et al.]. Isoliquiritigenin-Induced Differentiation in Mouse Melanoma B16F0 Cell Line. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-479402
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479402
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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