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Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats
المؤلفون المشاركون
Zhang, Hao
Zhang, Jianzheng
Wang, Xiaowei
Liu, Jia
Sun, Tiansheng
Liu, Zhi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pulmonary infections frequently occur following hip fracture surgery in aged patients.
However, the underlying reasons are not fully understood.
The present study investigates the systemic inflammatory response and pulmonary conditions following hip fracture surgery as a means of identifying risk factors for lung infections using an aged rodent model.
Aged, male Sprague-Dawley rats (8 animals per group) underwent a sham procedure or hip fracture plus femoral intramedullary pinning.
Animals were sacrificed 1, 3, and 7 days after the injury.
Markers of systemic inflammation and pulmonary injury were analyzed.
Both sham-operated and injured/surgical group animals underwent intratracheal inoculation with Pseudomonas aeruginosa 1, 3, and 7 days after surgery.
P.
aeruginosa counts in blood and bronchoalveolar lavage (BAL) fluid and survival rates were recorded.
Serum TNF-α, IL-6, IL-1β, and IL-10 levels and markers of pulmonary injury were significantly increased at 1 and 3 days following hip fracture and surgery.
Animals challenged with P.
aeruginosa at 1 and 3 days after injury had a significantly decreased survival rate and more P.
aeruginosa recovered from blood and BAL fluid.
This study shows that hip fracture and surgery in aged rats induced a systemic inflammatory response and lung injury associated with increased susceptibility to infection during the acute phase after injury and surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Hao& Sun, Tiansheng& Liu, Zhi& Zhang, Jianzheng& Wang, Xiaowei& Liu, Jia. 2013. Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Hao…[et al.]. Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-479526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Hao& Sun, Tiansheng& Liu, Zhi& Zhang, Jianzheng& Wang, Xiaowei& Liu, Jia. Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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