Immune Biomarker Response Depends on Choice of Experimental Pain Stimulus in Healthy Adults : A Preliminary Study
المؤلفون المشاركون
Riley, Joseph L.
Cruz-Almeida, Yenisel
Wallet, Shannon M.
King, Christopher D.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Few studies in healthy subjects have examined the neuroimmune responses associated with specific experimental pain stimuli, while none has measured multiple biomarkers simultaneously.
The aim of the present study was to compare the neuro-immune responses following two common experimental pain stimuli: cold pressor test (CPT) and focal heat pain (FHP).
Eight adults participated in two counterbalanced experimental sessions of FHP or CPT with continuous pain ratings and blood sampling before and 30 minutes after the sessions.
Despite similar pain intensity ratings (FHP = 42.2±15.3; CPT = 44.5±34.1; P=0.871), CPT and FHP induced different neuro-immune biomarker responses.
CPT was accompanied by significant increases in cortisol (P=0.046) and anti-inflammatory cytokine IL-10 (P=0.043) with significant decreases in several pro-inflammatory mediators (IL-1β (P=0.028), IL-12 (P=0.012), TNF-α (P=0.039), and MCP-1 (P=0.038)).
There were nonsignificant biomarker changes during the FHP session.
There were close to significant differences between the sessions for IL-1β (P=0.081), IFN-γ (P=0.072), and IL-12 (P=0.053) with biomarkers decreasing after CPT and increasing after FHP.
There were stronger associations between catastrophizing and most biomarkers after CPT compared to FHP.
Our results suggest that CPT is a stressful and painful stimulus, while FHP is mostly a painful stimulus.
Thus, each experimental pain stimulus can activate different neuro-immune cascades, which are likely relevant for the interpretation of studies in chronic pain conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cruz-Almeida, Yenisel& King, Christopher D.& Wallet, Shannon M.& Riley, Joseph L.. 2012. Immune Biomarker Response Depends on Choice of Experimental Pain Stimulus in Healthy Adults : A Preliminary Study. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cruz-Almeida, Yenisel…[et al.]. Immune Biomarker Response Depends on Choice of Experimental Pain Stimulus in Healthy Adults : A Preliminary Study. Pain Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-479739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cruz-Almeida, Yenisel& King, Christopher D.& Wallet, Shannon M.& Riley, Joseph L.. Immune Biomarker Response Depends on Choice of Experimental Pain Stimulus in Healthy Adults : A Preliminary Study. Pain Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-479739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر