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Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid
المؤلفون المشاركون
Boridy, Sebastien
Maysinger, Dusica
Chang, P. K.-Y.
McKinney, R. A.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Reduced estrogens, either through aging or postsurgery breast cancer treatment with the oral nonsteroidal aromatase inhibitor letrozole, are linked with declined cognitive abilities.
However, a direct link between letrozole and neuronal deficits induced by pathogenic insults associated with aging such as beta amyloid (Aβ1–42) has not been established.
The objective of this study was to determine if letrozole aggravates synaptic deficits concurrent with Aβ1–42 insult.
We examined the effects of letrozole and oligomeric Aβ1–42 treatment in dissociated and organotypic hippocampal slice cultures.
Changes in glial cell morphology, neuronal mitochondria, and synaptic structures upon letrozole treatment were monitored by confocal microscopy, as they were shown to be affected by Aβ1–42 oligomers.
Oligomeric Aβ1–42 or letrozole alone caused decreases in mitochondrial volume, dendritic spine density, synaptophysin (synaptic marker), and the postsynaptic protein, synaptopodin.
Here, we demonstrated that mitochondrial and synaptic structural deficits were exacerbated when letrozole therapy was combined with Aβ1–42 treatment.
Our novel findings suggest that letrozole may increase neuronal susceptibility to pathological insults, such as oligomeric Aβ1–42 in Alzheimer’s disease (AD).
These changes in dendritic spine number, synaptic protein expression, and mitochondrial morphology may, in part, explain the increased prevalence of cognitive decline associated with aromatase inhibitor use.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, P. K.-Y.& Boridy, Sebastien& McKinney, R. A.& Maysinger, Dusica. 2013. Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid. Journal of Aging Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, P. K.-Y.…[et al.]. Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid. Journal of Aging Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-479748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, P. K.-Y.& Boridy, Sebastien& McKinney, R. A.& Maysinger, Dusica. Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid. Journal of Aging Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-479748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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