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Neuroprotective Effects of Adipose-Derived Stem Cells Are Maintained for 3 Weeks against Ischemic Damage in the Rabbit Spinal Cord
المؤلفون المشاركون
Kim, Woosuk
Choi, Jung Hoon
Jung, Hyo Young
Hwang, In Koo
Im, Wooseok
Moon, Seung Myung
Won, Moo-Ho
Yoo, Dae Young
Chung, Jin Young
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
In the previous study, we demonstrated that adipose-derived stem cells (ASCs) have neuroprotective effects against ischemic damage in the ventral horn of L5-6 levels at 3 days after ischemia/reperfusion.
In the present study, we expanded our observations for 3 weeks after ischemia/reperfusion to rule out the possibility of delayed neuronal death in several days after ischemia/reperfusion.
Transient spinal cord ischemia was induced by a 15 min aortic artery occlusion in the subrenal region and rabbit ASCs were administered intrathecally into recipient rabbits (2×105) immediately after reperfusion.
Transplantation of ASCs improved the neurological motor functions of the hindlimb 3 weeks after ischemia/reperfusion.
Similarly, the cresyl violet-positive neurons were significantly increased at 3 weeks after ischemia/reperfusion compared to that in the vehicle (artificial cerebrospinal fluid)-treated group.
The transplantation of ASCs significantly reduced reactive microglia induced by ischemia at 3 weeks after ischemia/reperfusion.
In addition, transplantation of ASCs maintained the brain-derived neurotrophic factor (BDNF) levels 3 weeks after ischemia/reperfusion.
These results suggest that the neuroprotective effects of ASCs are maintained 3 weeks after ischemia/reperfusion by modulating microgliosis and BDNF levels in the spinal cord.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moon, Seung Myung& Kim, Woosuk& Chung, Jin Young& Im, Wooseok& Yoo, Dae Young& Jung, Hyo Young…[et al.]. 2014. Neuroprotective Effects of Adipose-Derived Stem Cells Are Maintained for 3 Weeks against Ischemic Damage in the Rabbit Spinal Cord. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moon, Seung Myung…[et al.]. Neuroprotective Effects of Adipose-Derived Stem Cells Are Maintained for 3 Weeks against Ischemic Damage in the Rabbit Spinal Cord. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-479752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moon, Seung Myung& Kim, Woosuk& Chung, Jin Young& Im, Wooseok& Yoo, Dae Young& Jung, Hyo Young…[et al.]. Neuroprotective Effects of Adipose-Derived Stem Cells Are Maintained for 3 Weeks against Ischemic Damage in the Rabbit Spinal Cord. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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