IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population
المؤلفون المشاركون
Huebner, Claudia
Han, Dug-Yeo
Morgan, Angharad R.
Ferguson, Lynnette R.
Lam, Wen-Jiun
Fraser, Alan G.
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
DNA samples from 339 Crohn's disease (CD) and 407 randomly selected controls from the Auckland (New Zealand) IBD project, were genotyped for five common single nucleotide polymorphisms in IL-23R (rs11805303, rs7517847, rs1343151, rs11209026, and rs10889677) and two in IL-12B (rs1363670 and rs6887695).
While the IL-12B variants did not show an overall association and other IL23R variants led to minor changes in the risk of CD, rs1343151 and/or rs7517847 variants in the IL-23R gene strongly reduced the risk of developing CD at both allelic and genotype levels.
A significantly decreased risk of first diagnosis of childhood CD was observed in individuals carrying the A allele of rs1343151, or between 17–40 y in individuals carrying the G allele in rs7517847 of IL-23R.
A significantly decreased risk of ileocolonic or structuring disease was observed in individuals carrying the A allele in either rs11209026 or rs1343151, or the G allele in rs7517847 of IL-23R, and when such individuals did develop the disease, they were unlikely to require a bowel resection.
Certain haplotypes very strongly modified risk.
There was evidence for interactions of IL-23R variants with the NOD2 wild-type (d/d) genotype.
Down-regulating the function of the IL-23R gene may decrease CD risk in the normal population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferguson, Lynnette R.& Han, Dug-Yeo& Fraser, Alan G.& Huebner, Claudia& Lam, Wen-Jiun& Morgan, Angharad R.. 2010. IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-479807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferguson, Lynnette R.…[et al.]. IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population. Gastroenterology Research and Practice No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-479807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferguson, Lynnette R.& Han, Dug-Yeo& Fraser, Alan G.& Huebner, Claudia& Lam, Wen-Jiun& Morgan, Angharad R.. IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-479807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر