Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves : Comparison with Those of Local Anesthetics
المؤلفون المشاركون
Hirakawa, Naomi
Uemura, Yuhei
Fujita, Tsugumi
Sakaguchi, Yoshiro
Kumamoto, Eiichi
Ohtsubo, Sena
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Antiepileptics used for treating neuropathic pain have various actions including voltage-gated Na+ and Ca2+ channels, glutamate-receptor inhibition, and GABAA-receptor activation, while local anesthetics are also used to alleviate the pain.
It has not been fully examined yet how nerve conduction inhibitions by local anesthetics differ in extent from those by antiepileptics.
Fast-conducting compound action potentials (CAPs) were recorded from frog sciatic nerve fibers by using the air-gap method.
Antiepileptics (lamotrigine and carbamazepine) concentration dependently reduced the peak amplitude of the CAP (IC50=0.44 and 0.50 mM, resp.).
Carbamazepine analog oxcarbazepine exhibited an inhibition smaller than that of carbamazepine.
Antiepileptic phenytoin (0.1 mM) reduced CAP amplitude by 15%.
On the other hand, other antiepileptics (gabapentin, sodium valproate, and topiramate) at 10 mM had no effect on CAPs.
The CAPs were inhibited by local anesthetic levobupivacaine (IC50=0.23 mM).
These results indicate that there is a difference in the extent of nerve conduction inhibition among antiepileptics and that some antiepileptics inhibit nerve conduction with an efficacy similar to that of levobupivacaine or to those of other local anesthetics (lidocaine, ropivacaine, and cocaine) as reported previously.
This may serve to know a contribution of nerve conduction inhibition in the antinociception by antiepileptics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uemura, Yuhei& Fujita, Tsugumi& Ohtsubo, Sena& Hirakawa, Naomi& Sakaguchi, Yoshiro& Kumamoto, Eiichi. 2014. Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves : Comparison with Those of Local Anesthetics. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479875
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uemura, Yuhei…[et al.]. Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves : Comparison with Those of Local Anesthetics. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-479875
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uemura, Yuhei& Fujita, Tsugumi& Ohtsubo, Sena& Hirakawa, Naomi& Sakaguchi, Yoshiro& Kumamoto, Eiichi. Effects of Various Antiepileptics Used to Alleviate Neuropathic Pain on Compound Action Potential in Frog Sciatic Nerves : Comparison with Those of Local Anesthetics. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479875
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479875
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر