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The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia
المؤلفون المشاركون
Kulkarni, Jayashri
Gavrilidis, Emorfia
Hayes, Emily
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The theory that many serious mental illnesses, in particular psychoses such as schizophrenia, may have a significant hormonal aetiological component is fast gaining popularity and the support of scientific evidence.
Oestrogen in particular has been substantially investigated as a potential mediator of brain function in schizophrenia.
Epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women suggests a protective role of oestrogen.
In vitro and in vivo preclinical research confirms oestradiol’s interactions with central neurotransmitter systems implicated in the pathogenesis of schizophrenia, while results from randomised controlled trials investigating the antipsychotic potential of oestrogen have been positive.
Research into other neuroactive hormones with possible effects on mental state is a rapidly evolving field that may hold new promise.
Given that schizophrenia and related psychoses are pervasive and debilitating conditions for which currently available treatments are often only partially effective and entail a high risk of serious side-effects, novel therapeutic strategies are needed.
The literature reviewed in this paper suggests that hormones such as oestrogen could be a viable option, and it is hoped that with further research and larger trials, the oestrogen hypothesis can be translated into effective clinical practice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hayes, Emily& Gavrilidis, Emorfia& Kulkarni, Jayashri. 2012. The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia. Schizophrenia Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hayes, Emily…[et al.]. The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia. Schizophrenia Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-479878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hayes, Emily& Gavrilidis, Emorfia& Kulkarni, Jayashri. The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia. Schizophrenia Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-479878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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