Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64
المؤلفون المشاركون
Mustofa, Mustofa
Jumina, Jumina
Supargiyono, Supargiyono
Sholikhah, Eti Nurwening
Hadanu, Ruslin
Wijayanti, Mahardika Agus
المصدر
Malaria Research and Treatment
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Potential new targets for antimalarial chemotherapy include parasite proteases, which are required for several cellular functions during the Plasmodium falciparum life cycle.
Four new derivatives of N-alkyl and N-benzyl-1,10-phenanthroline have been synthesized.
Those are (1)-N-methyl-1,10-phenanthrolinium sulfate, (1)-N-ethyl-1,10-phenanthrolinium sulfate, (1)-N-benzyl-1,10-phenanthrolinium chloride, and (1)-N-benzyl-1,10-phenanthrolinium iodide.
Those compounds had potential antiplasmodial activity with IC50 values from 260.42 to 465.38 nM.
Cysteine proteinase inhibitor E64 was used to investigate the mechanism of action of N-alkyl and N-benzyl-1,10-phenanthroline derivatives.
A modified fixed-ratio isobologram method was used to study the in vitro interactions between the new compounds with either E64 or chloroquine.
The interaction between N-alkyl and N-benzyl-1,10-phenanthroline derivatives and E64 was additive as well as their interactions with chloroquine were also additive.
Antimalarial mechanism of chloroquine is mainly on the inhibition of hemozoin formation.
As the interaction of chloroquine and E64 was additive, the results indicated that these new compounds had a mechanism of action by inhibiting Plasmodium proteases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wijayanti, Mahardika Agus& Sholikhah, Eti Nurwening& Hadanu, Ruslin& Jumina, Jumina& Supargiyono, Supargiyono& Mustofa, Mustofa. 2010. Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64. Malaria Research and Treatment،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479925
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wijayanti, Mahardika Agus…[et al.]. Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64. Malaria Research and Treatment No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-479925
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wijayanti, Mahardika Agus& Sholikhah, Eti Nurwening& Hadanu, Ruslin& Jumina, Jumina& Supargiyono, Supargiyono& Mustofa, Mustofa. Additive In Vitro Antiplasmodial Effect of N-Alkyl and N-Benzyl-1,10-Phenanthroline Derivatives and Cysteine Protease Inhibitor E64. Malaria Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-479925
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-479925
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر