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Image Guided Hypofractionated Radiotherapy by Helical Tomotherapy for Prostate Carcinoma : Toxicity and Impact on Nadir PSA
المؤلفون المشاركون
Marcenaro, Michela
Gusinu, Marco
Vidano, Giulia
Timon, Giorgia
Vagge, Stefano
Blandino, Gladys
Corvò, Renzo
Agnese, Dario
Cavagnetto, Francesca
Barra, Salvina
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the toxicity of a hypofractionated schedule for primary radiotherapy (RT) of prostate cancer as well as the value of the nadir PSA (nPSA) and time to nadir PSA (tnPSA) as surrogate efficacy of treatment.
Material and Methods.
Eighty patients underwent hypofractionated schedule by Helical Tomotherapy (HT).
A dose of 70.2 Gy was administered in 27 daily fractions of 2.6 Gy.
Acute and late toxicities were graded on the RTOG/EORTC scales.
The nPSA and the tnPSA for patients treated with exclusive RT were compared to an equal cohort of 20 patients treated with conventional fractionation and standard conformal radiotherapy.
Results.
Most of patients (83%) did not develop acute gastrointestinal (GI) toxicity and 50% did not present genitourinary (GU) toxicity.
After a median follow-up of 36 months only grade 1 of GU and GI was reported in 6 and 3 patients as late toxicity.
Average tnPSA was 30 months.
The median value of nPSA after exclusive RT with HT was 0.28 ng/mL and was significantly lower than the median nPSA (0.67 ng/mL) of the conventionally treated cohort (P=0.02).
Conclusions.
Hypofractionated RT schedule with HT for prostate cancer treatment reports very low toxicity and reaches a low level of nPSA that might correlate with good outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barra, Salvina& Vagge, Stefano& Marcenaro, Michela& Blandino, Gladys& Timon, Giorgia& Vidano, Giulia…[et al.]. 2014. Image Guided Hypofractionated Radiotherapy by Helical Tomotherapy for Prostate Carcinoma : Toxicity and Impact on Nadir PSA. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barra, Salvina…[et al.]. Image Guided Hypofractionated Radiotherapy by Helical Tomotherapy for Prostate Carcinoma : Toxicity and Impact on Nadir PSA. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-480045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barra, Salvina& Vagge, Stefano& Marcenaro, Michela& Blandino, Gladys& Timon, Giorgia& Vidano, Giulia…[et al.]. Image Guided Hypofractionated Radiotherapy by Helical Tomotherapy for Prostate Carcinoma : Toxicity and Impact on Nadir PSA. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-480045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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