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Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy
المؤلفون المشاركون
Martinez-Castillo, Sebastián
Diaz-Llopis, Manuel
Morales, José M.
Pinazo-Durán, María Dolores
Galbis-Estrada, Carmen
Vivar-Llopis, Bárbara
Monleón, Daniel
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We used 1H NMR spectroscopy to analyze the metabolomic profile of reflex tears from patients with dry eye disorders (DEDs).
90 subjects were divided into 2 groups: (1) patients with DEDs (DEDG; n = 55) and (2) healthy subjects (CG; n = 35).
Additionally, the DEDG was subdivided into 2 subgroups based on DED severity: mild-to-moderate and moderate (n = 22 and n = 33, resp.).
Personal interviews and systematized ophthalmologic examinations were carried out.
Reflex tears (20–30 μL) were collected by gently rubbing in the inferior meniscus of both eyelids with a microglass pipette and stored at −80°C until analysis.
NMR spectra were acquired using a standard one-dimensional pulse sequence with water suppression.
Data were processed and transferred to MATLAB for further chemometric analysis.
Main differences in tear composition between DEDG and CG were found in cholesterol, N-acetylglucosamine, glutamate, creatine, amino-n-butyrate, choline, acetylcholine, arginine, phosphoethanolamine, glucose, and phenylalanine levels.
This metabolic fingerprint helped also to discriminate between the three additional subgroups of DEDG.
Our results suggest that tear metabolic differences between DEDG and CG identified by NMR could be useful in understanding ocular surface pathogenesis and improving biotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Galbis-Estrada, Carmen& Martinez-Castillo, Sebastián& Morales, José M.& Vivar-Llopis, Bárbara& Monleón, Daniel& Diaz-Llopis, Manuel…[et al.]. 2014. Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Galbis-Estrada, Carmen…[et al.]. Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-480109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Galbis-Estrada, Carmen& Martinez-Castillo, Sebastián& Morales, José M.& Vivar-Llopis, Bárbara& Monleón, Daniel& Diaz-Llopis, Manuel…[et al.]. Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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