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HPLC-DAD Analysis, Antileishmanial, Antiproliferative, and Antibacterial Activities of Lacistema pubescens : An Amazonian Medicinal Plant
المؤلفون المشاركون
Antinarelli, Luciana Maria Ribeiro
Pinto, Nícolas de Castro Campos
Coimbra, Elaine Soares
Ribeiro, Antônia
Mello da Silva, Josiane
de Souza-Fagundes, Elaine Maria
Scio, Elita
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Species of the genus Lacistema are traditionally used by Brazilian and Peruvian indigenous communities.
The present study investigated the in vitro antileishmanial activity against several Leishmania species, cytotoxicity in murine peritoneal macrophages, antiproliferative activity against HL60 and Jurkat cells, and antibacterial activities against seven bacteria strains of the aerial parts of the methanolic crude extract and fractions of Lacistema pubescens.
In addition, their chemical profile was also evaluated.
Hexane fraction showed the most significant IC50 values against all promastigotes of Leishmania species tested, except for L.
chagasi (IC50 = 4.2 µg/mL for L.
major and IC50 = 3.5 µg/mL for L.
amazonensis).
This fraction also exhibited a strong activity against amastigotes of L.
amazonensis (IC50 = 6.9 µg/mL).
The antiproliferative activity was also observed for methanolic extract and hexane fraction with IC50 = 47.2 µg/mL and IC50 = 39.7 µg/mL for HL60, respectively.
Regarding the antimicrobial activity, the overall antibacterial activity was not very significative.
Phytol and sitosterol were identified in the methanolic extract.
Additionally, previous studies also revealed the presence of those compounds in the hexane fraction.
Among other compounds, phytol and sitosterol were probably involved in the antileishmanial and cytotoxicity activities observed in this study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mello da Silva, Josiane& Antinarelli, Luciana Maria Ribeiro& Pinto, Nícolas de Castro Campos& Coimbra, Elaine Soares& de Souza-Fagundes, Elaine Maria& Ribeiro, Antônia…[et al.]. 2014. HPLC-DAD Analysis, Antileishmanial, Antiproliferative, and Antibacterial Activities of Lacistema pubescens : An Amazonian Medicinal Plant. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mello da Silva, Josiane…[et al.]. HPLC-DAD Analysis, Antileishmanial, Antiproliferative, and Antibacterial Activities of Lacistema pubescens : An Amazonian Medicinal Plant. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-480258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mello da Silva, Josiane& Antinarelli, Luciana Maria Ribeiro& Pinto, Nícolas de Castro Campos& Coimbra, Elaine Soares& de Souza-Fagundes, Elaine Maria& Ribeiro, Antônia…[et al.]. HPLC-DAD Analysis, Antileishmanial, Antiproliferative, and Antibacterial Activities of Lacistema pubescens : An Amazonian Medicinal Plant. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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