α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway
المؤلفون المشاركون
Li, Xuqi
Wu, Erxi
Sheng, Liang
Hu, Ang
Ma, Jiguang
Duan, Wanxing
Lei, Jianjun
Ma, Qingyong
Chen, Xin
Wang, Zheng
Wu, Zheng
Xu, Qinhong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
α-Mangostin, a natural product isolated from the pericarp of the mangosteen fruit, has been shown to inhibit the growth of tumor cells in various types of cancers.
However, the underlying molecular mechanisms are largely unclear.
Here, we report that α-mangostin suppressed the viability and epithelial-mesenchymal transition (EMT) of pancreatic cancer cells through inhibition of the PI3K/Akt pathway.
Treatment of pancreatic cancer BxPc-3 and Panc-1 cells with α-mangostin resulted in loss of cell viability, accompanied by enhanced cell apoptosis, cell cycle arrest at G1 phase, and decrease of cyclin-D1.
Moreover, Transwell and Matrigel invasion assays showed that α-mangostin significantly reduced the migration and invasion of pancreatic cancer cells.
Consistent with these results, α-mangostin decreased the expression of MMP-2, MMP-9, N-cadherin, and vimentin and increased the expression of E-cadherin.
Furthermore, we found that α-mangostin suppressed the activity of the PI3K/Akt pathway in pancreatic cancer cells as demonstrated by the reduction of the Akt phosphorylation by α-mangostin.
Finally, α-mangostin significantly inhibited the growth of BxPc-3 tumor mouse xenografts.
Our results suggest that α-mangostin may be potentially used as a novel adjuvant therapy or complementary alternative medicine for the management of pancreatic cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Qinhong& Ma, Jiguang& Lei, Jianjun& Duan, Wanxing& Sheng, Liang& Chen, Xin…[et al.]. 2014. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Qinhong…[et al.]. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-480366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Qinhong& Ma, Jiguang& Lei, Jianjun& Duan, Wanxing& Sheng, Liang& Chen, Xin…[et al.]. α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3KAkt Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-480366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر