Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation : Clinical Toxicity Observations and Retrospective Daily Dosimetry
المؤلفون المشاركون
Fiveash, John B.
Wu, Xingen
Yang, Eddy S.
Dobelbower, Michael C.
McDonald, Andrew M.
Jacob, Rojymon
Bishop, Justin M.
Kim, Robert Y.
Smith, Heather
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate toxicity associated with the addition of elective nodal irradiation (ENI) to a hypofractionated regimen for the treatment of prostate cancer.
Methods and Materials.
Fifty-seven patients received pelvic image-guided IMRT to 50.4 Gy in 28 fractions with a hypofractionated simultaneous boost to the prostate to 70 Gy.
Thirty-one patients received prostate-only treatment to 70 Gy in 28 fractions.
Results.
Median followup was 41.1 months.
Early grade ≥2 urinary toxicity rates were 49% (28 of 57) for patients receiving ENI and 58% (18 of 31) for those not (P=0.61).
Early grade ≥2 rectal toxicity rates were 40% (23 of 57) and 23% (7 of 31), respectively (P=0.09).
The addition of ENI resulted in a 21% actuarial rate of late grade ≥2 rectal toxicity at 4 years, compared to 0% for patients treated to the prostate only (P=0.02).
Retrospective daily dosimetry of patients experiencing late rectal toxicity revealed an average increase of 2.67% of the rectal volume receiving 70 Gy compared to the original plan.
Conclusions.
The addition of ENI resulted in an increased risk of late rectal toxicity.
Grade ≥2 late rectal toxicity was associated with worse daily rectal dosimetry compared to the treatment plan.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McDonald, Andrew M.& Bishop, Justin M.& Jacob, Rojymon& Dobelbower, Michael C.& Kim, Robert Y.& Yang, Eddy S.…[et al.]. 2012. Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation : Clinical Toxicity Observations and Retrospective Daily Dosimetry. Prostate Cancer،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McDonald, Andrew M.…[et al.]. Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation : Clinical Toxicity Observations and Retrospective Daily Dosimetry. Prostate Cancer No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-480400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McDonald, Andrew M.& Bishop, Justin M.& Jacob, Rojymon& Dobelbower, Michael C.& Kim, Robert Y.& Yang, Eddy S.…[et al.]. Hypofractionated Prostate Radiotherapy with or without Conventionally Fractionated Nodal Irradiation : Clinical Toxicity Observations and Retrospective Daily Dosimetry. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-480400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر