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NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3KAkt-Rac1-JNK and ERK Pathways
المؤلفون المشاركون
Hu, Hou-Wen
Zhang, Fa-Biao
Wei, Xiao-Jie
Chen, Rui-Jie
Chen, Ji-Cai
Zhu, Yan-An
Lu, Cai-Jiao
Jin, Wen-Yang
Lin, Cai
Lin, Bei-Bei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
As a well-known neurotrophic factor, nerve growth factor (NGF) has also been extensively recognized for its acceleration of healing in cutaneous wounds in both animal models and randomized clinical trials.
However, the underlying mechanisms accounting for the therapeutic effect of NGF on skin wounds are not fully understood.
NGF treatment significantly accelerated the rate of wound healing by promoting wound reepithelialization, the formation of granulation tissue, and collagen production.
To explore the possible mechanisms of this process, the expression levels of CD68, VEGF, PCNA, and TGF-β1 in wounds were detected by immunohistochemical staining.
The levels of these proteins were all significantly raised in NGF-treated wounds compared to untreated controls.
NGF also significantly promoted the migration, but not the proliferation, of dermal fibroblasts.
NGF induced a remarkable increase in the activity of PI3K/Akt, JNK, ERK, and Rac1, and blockade with their specific inhibitors significantly impaired the NGF-induced migration.
In conclusion, NGF significantly accelerated the healing of skin excisional wounds in rats and the fibroblast migration induced by NGF may contribute to this healing process.
The activation of PI3K/Akt, Rac1, JNK, and ERK were all involved in the regulation of NGF-induced fibroblast migration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Ji-Cai& Lin, Bei-Bei& Hu, Hou-Wen& Lin, Cai& Jin, Wen-Yang& Zhang, Fa-Biao…[et al.]. 2014. NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3KAkt-Rac1-JNK and ERK Pathways. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-480436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Ji-Cai…[et al.]. NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3KAkt-Rac1-JNK and ERK Pathways. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-480436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Ji-Cai& Lin, Bei-Bei& Hu, Hou-Wen& Lin, Cai& Jin, Wen-Yang& Zhang, Fa-Biao…[et al.]. NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3KAkt-Rac1-JNK and ERK Pathways. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-480436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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