Vascular Guidance : Microstructural Scaffold Patterning for Inductive Neovascularization
المؤلفون المشاركون
Whiteman, Matthew
Muller, Daniel
Chim, Harvey
Bader, Augustinus
Schantz, Jan-Thorsten
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-01
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Current tissue engineering techniques are limited by inadequate vascularisation and perfusion of cell-scaffold constructs.
Microstructural patterning through biomimetic vascular channels within a polymer scaffold might induce neovascularization, allowing fabrication of large engineered constructs.
The network of vascular channels within a frontal-parietal defect in a patient, originating from the anterior branch of the middle meningeal artery, was modeled using computer-aided design (CAD) techniques and subsequently incorporated into polycaprolactone (PCL) scaffolds fabricated using fused deposition modeling (FDM).
Bone marrow-derived mesenchymal stem cells (MSCs) were seeded onto the scaffolds and implanted into a rat model, with an arteriovenous bundle inserted at the proximal extent of the vascular network.
After 3 weeks, scaffolds were elevated as a prefabricated composite tissue-polymer flap and transferred using microsurgical technique.
Histological examination of explanted scaffolds revealed vascular ingrowth along patterned channels, with abundant capillary and connective tissue formation throughout experimental scaffolds, while control scaffolds showed only granulation tissue.
All prefabricated constructs transferred as free flaps survived and were viable.
We term this concept “vascular guidance,” whereby neovascularization is guided through customized channels in a scaffold.
Our technique might potentially allow fabrication of much larger tissue-engineered constructs than current technologies allow, as well as allowing tailored construct fabrication with a patient-specific vessel network based on CT scan data and CAD technology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muller, Daniel& Chim, Harvey& Bader, Augustinus& Whiteman, Matthew& Schantz, Jan-Thorsten. 2010. Vascular Guidance : Microstructural Scaffold Patterning for Inductive Neovascularization. Stem Cells International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-480441
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muller, Daniel…[et al.]. Vascular Guidance : Microstructural Scaffold Patterning for Inductive Neovascularization. Stem Cells International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-480441
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muller, Daniel& Chim, Harvey& Bader, Augustinus& Whiteman, Matthew& Schantz, Jan-Thorsten. Vascular Guidance : Microstructural Scaffold Patterning for Inductive Neovascularization. Stem Cells International. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-480441
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480441
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر