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Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient
المؤلفون المشاركون
Feist, Ashley A.
Shah, Mita M.
Masters, Joanna C.
المصدر
Case Reports in Transplantation
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-02
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Purpose.
The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported.
Summary.
The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions.
The patient, a 57-year-old Caucasian male kidney transplant recipient, was stable for years on sirolimus as his primary immunosuppressive agent and had a history of chronic angina, for which he was prescribed ranolazine.
Upon addition and dose escalation of ranolazine, whole blood sirolimus levels more than tripled, rising to immeasurably high concentrations.
After holding sirolimus on multiple occasions and reducing dosage more than 50%, blood levels returned to therapeutic range, while continuing ranolazine.
Conclusion.
Since ranolazine is a documented P-GP and CYP3A inhibitor, and sirolimus a known substrate for both pathways, it is proposed that ranolazine inhibition of P-GP and CYP3A4 contributed to the significant elevation in sirolimus exposure.
No alternative causes for the rise in sirolimus exposure were found, and assessment with the Drug Interaction Probability Scale finds this interaction to be probable.
Clinicians should be aware of the potential for this interaction to cause elevated sirolimus exposure and subsequent increase in clinical effect or toxicity, in this case overimmunosuppression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masters, Joanna C.& Shah, Mita M.& Feist, Ashley A.. 2014. Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient. Case Reports in Transplantation،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-480532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masters, Joanna C.…[et al.]. Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient. Case Reports in Transplantation No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-480532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masters, Joanna C.& Shah, Mita M.& Feist, Ashley A.. Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient. Case Reports in Transplantation. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-480532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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