HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India
المؤلفون المشاركون
Subbakrishna, D. K.
Satish, Bhuthaiah
Satish, Kadappa Shivappa
Kondaiah, Paturu
Jagannathan, Latha
Balakrishnan, Kamala
Satishchandra, Parthasarathy
Chaturvedi, Mrinalini
Desai, Anita
Pitchappan, Ramasamy
Ravi, Vasanthapuram
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Substantial evidence exists for HLA and other host genetic factors being determinants of susceptibility or resistance to infectious diseases.
However, very little information is available on the role of host genetic factors in HIV-TB coinfection.
Hence, a longitudinal study was undertaken to investigate HLA associations in a cohort of HIV seropositive individuals with and without TB in Bangalore, South India.
Methods.
A cohort of 238 HIV seropositive subjects were typed for HLA-A, B, and DR by PCR-SSP and followed up for 5 years or till manifestation of Tuberculosis.
HLA data of 682 HIV Negative healthy renal donors was used as control.
Results.
The ratio of males and females in HIV cohort was comparable (50.4% and 49.6%).
But the incidence of TB was markedly lower in females (12.6%,) than males (25.6%).
Further, HLA-B*57 frequency in HIV cohort was significantly higher among females without TB (21.6%, 19/88) than males (1.7%, 1/59); P=0.0046; OR=38.
CD4 counts also were higher among females in this cohort.
Conclusion.
This study suggests that HIV positive women with HLA-B*57 have less occurrence of TB as compared to males.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jagannathan, Latha& Chaturvedi, Mrinalini& Satish, Bhuthaiah& Satish, Kadappa Shivappa& Desai, Anita& Subbakrishna, D. K.…[et al.]. 2011. HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jagannathan, Latha…[et al.]. HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India. Clinical and Developmental Immunology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-480614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jagannathan, Latha& Chaturvedi, Mrinalini& Satish, Bhuthaiah& Satish, Kadappa Shivappa& Desai, Anita& Subbakrishna, D. K.…[et al.]. HLA-B∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر