Compression of Multilayered Composite Electrospun Scaffolds : A Novel Strategy to Rapidly Enhance Mechanical Properties and Three Dimensionality of Bone Scaffolds
المؤلفون المشاركون
Rodriguez, Isaac A.
Madurantakam, Parthasarathy A.
Bowlin, Gary L.
Garg, Koyal
McCool, Jennifer M.
Moon, Peter C.
المصدر
Advances in Materials Science and Engineering
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الهندسية و تكنولوجيا المعلومات
الملخص EN
One major limitation of electrospun scaffolds intended for bone tissue engineering is their inferior mechanical properties.
The present study introduces a novel strategy to engineer stiffer scaffolds by stacking multiple layers and cold welding them under high pressure.
Electrospun polydioxanone (PDO) and PDO:nanohydroxyapatite (PDO:nHA) scaffolds (1, 2, or 4 layered stacks) were compressed either before or after mineralizing treatment with simulated body fluid (SBF).
After two weeks in SBF, scaffolds were analyzed for total mineral content and stiffness by Alizarin red S and uniaxial tensile testing, respectively.
Scaffolds were also analyzed for permeability, pore size, and fiber diameter.
Results indicated that compression of multiple layers significantly increased the stiffness of scaffolds while reducing mineralization and permeability.
This phenomenon was attributed to increased density of fibers and loss of surface area due to fiber welding.
Statistics revealed, the 4-layered PDO:nHA scaffold compressed first followed by mineralization in revised SBF had maximal stiffness, low permeability and pore size, and mineralization second only to noncompressed scaffolds.
Within the limitations of permeability and pore size, this scaffold configuration represents an optimal midway for desired stiffness and mineral content for bone tissue engineering.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Madurantakam, Parthasarathy A.& Rodriguez, Isaac A.& Garg, Koyal& McCool, Jennifer M.& Moon, Peter C.& Bowlin, Gary L.. 2013. Compression of Multilayered Composite Electrospun Scaffolds : A Novel Strategy to Rapidly Enhance Mechanical Properties and Three Dimensionality of Bone Scaffolds. Advances in Materials Science and Engineering،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Madurantakam, Parthasarathy A.…[et al.]. Compression of Multilayered Composite Electrospun Scaffolds : A Novel Strategy to Rapidly Enhance Mechanical Properties and Three Dimensionality of Bone Scaffolds. Advances in Materials Science and Engineering No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Madurantakam, Parthasarathy A.& Rodriguez, Isaac A.& Garg, Koyal& McCool, Jennifer M.& Moon, Peter C.& Bowlin, Gary L.. Compression of Multilayered Composite Electrospun Scaffolds : A Novel Strategy to Rapidly Enhance Mechanical Properties and Three Dimensionality of Bone Scaffolds. Advances in Materials Science and Engineering. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر