![](/images/graphics-bg.png)
Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4NF-κB Pathway
المؤلفون المشاركون
Huang, He
Wu, Yuqing
Li, Xin
Zhou, Chenghua
Zhu, Yangzi
Zhou, Ce
Lu, Fuzhao
Liu, Yingchun
Huang, Li
Zhang, Yong
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Dexmedetomidine has been reported to reduce mortality in septic rats.
This study was designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung tissues of septic rats induced by CLP.
After induction of sepsis, the rats were treated with normal saline or dexmedetomidine (5, 10, or 20 μg/kg).
The survival rate of septic rats in 24 h was recorded.
The inflammation of lung tissues was evaluated by HE stain.
The concentrations of IL-6 and TNF-α in BALF and plasma were measured by ELISA.
The expressions of TLR4 and MyD88 were measured by western blotting.
The activation of NF-κB in rat lung tissues was assessed by western blotting and immunohistochemistry.
It was found that the mortality rate and pulmonary inflammation were significantly increased in septic rats.
IL-6 and TNF-α levels in BALF and plasma, NF-κB activity, and TLR4/MyD88 expression in rat lung tissues were markedly enhanced after CLP.
Dexmedetomidine (10 and 20 μg/kg) significantly decreased mortality and pulmonary inflammation of septic rats, as well as suppressed CLP-induced elevation of TNF-α and IL-6 and inhibited TLR4/MyD88 expression and NF-κB activation.
These results suggest that dexmedetomidine may decrease mortality and inhibit inflammatory reaction in lung tissues of septic rats by suppressing TLR4/MyD88/NF-κB pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yuqing& Liu, Yingchun& Huang, He& Zhu, Yangzi& Zhang, Yong& Lu, Fuzhao…[et al.]. 2013. Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4NF-κB Pathway. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yuqing…[et al.]. Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4NF-κB Pathway. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yuqing& Liu, Yingchun& Huang, He& Zhu, Yangzi& Zhang, Yong& Lu, Fuzhao…[et al.]. Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4NF-κB Pathway. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-480928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)