Biomarkers of Coagulation and Fibrinolysis during Cemented Total Hip Arthroplasty with Pre- versus Postoperative Start of Thromboprophylaxis
المؤلفون المشاركون
Reikeras, Olav
Borgen, Pål O.
Dahl, Ola E.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Venous thrombosis is common in elective hip surgery, and prophylaxis is recommended.
Clinical trials suggest that the drug dose and timing of initiating prophylaxis significantly influence antithrombotic effectiveness and safety.
We studied the time course and gradient of plasma coagulation and fibrinolysis during total hip arthroplasty (THA) in twenty patients that were randomly assigned to have the first dose of 5000 IU dalteparin subcutaneously (sc) injected 12 hours before or 6 hours after surgery.
Baseline characteristics were similar in both groups.
Specific biomarkers on coagulation (prothrombin fragment 1+2 (F1+2)) and fibrinolytic activity (plasmin/α2-antiplasmin complex (PAP) and D-dimer) were collected at six events during hospitalization and analysed.
There were no significant group differences in the biomarkers at any time point.
The highest concentrations were measured 6 hours after surgery and before the first postoperative injection.
A marked decrease followed at the first postoperative day, and then a second increase in plasma concentrations was observed 6 days after surgery.
This study showed that activation of coagulation and fibrinolysis by the operative trauma was the same when the first dose of dalteparin was injected 12 hours before or 6 hours after surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Borgen, Pål O.& Dahl, Ola E.& Reikeras, Olav. 2013. Biomarkers of Coagulation and Fibrinolysis during Cemented Total Hip Arthroplasty with Pre- versus Postoperative Start of Thromboprophylaxis. Thrombosis،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Borgen, Pål O.…[et al.]. Biomarkers of Coagulation and Fibrinolysis during Cemented Total Hip Arthroplasty with Pre- versus Postoperative Start of Thromboprophylaxis. Thrombosis No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-481034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Borgen, Pål O.& Dahl, Ola E.& Reikeras, Olav. Biomarkers of Coagulation and Fibrinolysis during Cemented Total Hip Arthroplasty with Pre- versus Postoperative Start of Thromboprophylaxis. Thrombosis. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر